Results 11 to 20 of about 3,643,521 (182)

Increasing Filamins A and B in Th2 Lymphocytes as a Therapeutic Opportunity to Attenuate Airway Inflammation in Mice. [PDF]

Allergy
Allergy, Volume 81, Issue 4, Page 1297-1301, April 2026.
Chamy L, Maire K, Hateb C, Subramaniam A, Deddouche-Grass S, Reber LL, Lutz PG, Lamsoul I.   +7 more
europepmc   +2 more sources

Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma? [PDF]

, 2014
The authors acknowledge the medical writing assistance received from Sam Yarwood, PhD, of Complete HealthVizion, in the form of literature searches and preparation and revision of the draft manuscript.Peer reviewedPublisher ...
Fromer, Leonard, Kaplan, Alan, Price, David, Román-Rodríguez, Miguel, van der Molen, Thys   +4 more
core   +11 more sources

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. [PDF]

, 2013
Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects.
Bratt, Jennifer M, Franzi, Lisa M, Kenyon, Nicholas J, Lam, Kit S, Lee, Joyce, Luo, Juntao, Zeki, Amir A   +6 more
core   +8 more sources

Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review. [PDF]

Basic Clin Pharmacol Toxicol
Mast cells drive early allergic asthma by releasing histamine, interleukins and prostaglandins, causing airway hyperresponsiveness, mucus overproduction and inflammation. These events sustain symptoms and promote structural remodelling, contributing to the progression of the disease.
Dos Santos IM, de Oliveira Rocha JL, de Alencar Filho EB, Silva FS.   +3 more
europepmc   +2 more sources

Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]

, 2018
The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J., Broad, Lisa M., Brooke, Simon M., Bundgaard, Christoffer, Christopoulos, Arthur, Crabtree, Michael D., Dwomoh, Louis, Felder, Christian C., Langmead, Christopher J., Mogg, Adrian J., Molloy, Colin, Sanger, Helen E., Sexton, Patrick M., Thompson, Karen J., Tobin, Andrew B.   +14 more
core   +1 more source

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma [PDF]

, 2017
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein–dependent signaling cascades.
Alexander Seidinger, Annika Simon, Barnes, Bernd K. Fleischmann, Chiba, Christa E. Müller, Daniela Wenzel, Evi Kostenis, Fuller, Gabriele M. König, Ian P. Hall, Kamato, Kawasaki, Kawasaki, Lee, Lelliott, Markus Kuschak, Michaela Matthey, Ralf Schröder, Richard Roberts, Suvi Annala   +20 more
core   +2 more sources

Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways

Respiratory Research, 2003
Background The link between eosinophils and the development of airway hyperresponsiveness (AHR) in asthma is still controversial. This question was assessed in a murine model of asthma in which we performed a dose ranging study to establish whether the ...
McCluskie Kerryn, Woodman Paul, Battram Cliff H, Birrell Mark A, Belvisi Maria G   +4 more
doaj   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony, Holz, Olaf, Janicki, Stanislawa, Jörres, Rudolf A., Kanniess, Frank, Magnussen, Helgo, Richter, Kai, Simpson, Kathy J., Tal-Singer, Ruth, Vessey, Rupert S. J.   +9 more
core   +1 more source

An electronic nose in the discrimination of patients with asthma and controls. [PDF]

, 2007
BACKGROUND: Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition.
Bel, Eh, Dragonieri, S, Gauw, Sa, LE CESSIE, S, Mertens, Bj, Rabe, Kf, Resta, O, Schot, R, Spanevello, Antonio, Sterk, Pj, Vink, Tj, Willard, Np   +11 more
core   +1 more source

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma [PDF]

, 2015
Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independent of confounding systemic considerations but ...
Anderson, Barnes, Bateman, Bates, Bianchi, Braman, Brancazio, Busse, Carvalho, Cazzola, Chen, Chew, Couch, Deninger, Diamant, Driehuys, Emami, Fiscus, Frazer, Frazer, Fuchs, Gershell, Glaab, Greenwald, Haczku, Haczku, Held, Held, Herget, Holmes, Hove, Hughes, Hughes-Riley, Hylkema, Kanekal, Kucharewicz, Kurucz, Lavoie, Lederlin, Lilburn, Lilburn, Martin, Masoli, Mistry, Nelson, Oenema, Raeburn, Sanderson, Siddiqui, Siegl, Six, Smith, Stevenson, Struhar, Tan, Thomas, Uhlig, Underwood, von Bethmann, Walker, Wohlsen, Zhao, Zosky   +62 more
core   +2 more sources