Results 21 to 30 of about 3,643,521 (182)

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Alcaraz L., Alikhani V., Anderson G. P., Austin R. P., Bao Y., Baur F., Bouyssou T., Cazzola M., Connolly S., Cooper A. E., Davies S. L., Deyrup M. D., Fuso L., Giles M. E., Green S. A, Kuna P., Matera M. G., Mortimer K. J., Patton J. S., Procopiou P. A., Procopiou P. A., Roig J., Stocks M. J., Tayab Z. R., Walker J. K. L., Walland A., White M. V.   +26 more
core   +2 more sources

Oxidative stress in asthmatic and non-asthmatic adolescent swimmers - a breathomics approach [PDF]

, 2017
We hypothesize that oxidative stress induced by trichloramine exposure during swimming could be related to etiopathogenesis of asthma among elite swimmers.
Barbosa, C, Couto, M, Delgado, L, Moreira, A, Rocha, SM, Rudnitskaya, A, Silva, D   +6 more
core   +1 more source

Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events [PDF]

, 2012
An increase in serious adverse events with both regular formoterol and regular salmeterol in chronic asthma has been demonstrated in previous Cochrane reviews.ObjectivesWe set out to compare the risks of mortality and non-fatal serious adverse events in ...
Altman, Blauw, Cates, Cates, Cates, Cates, Cates, Ducharme, Giembycz, Greenstone, Lipworth, Nelson, Ni Chroinin, Ni Chroinin, Pearce, Salpeter, Sears, Walters, Walters   +18 more
core   +1 more source

Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT [PDF]

, 2018
To understand the determinants of inhaled aerosol particle distribution and targeting in the lung, knowledge of regional deposition, lung morphology and regional ventilation, is crucial.
Albu, G., Bayat, S., Broche, L., Degrugilliers, L., Fodor, G. H., Habre, W., Petak, F., Porra, L., Sovijärvi, A. R. A., Strengell, S., Suhonen, H., Suortti, P.   +11 more
core   +5 more sources

Volatile Organic Compounds Contribute to Airway Hyperresponsiveness

The Korean Journal of Internal Medicine, 2007
Background Volatile organic compounds (VOCs) in concentrations found in both the work and home environments may influence lung function. We investigated the prevalence of airway responsiveness in workers exposed to VOCs.
A. Jang, I. Choi, Y. Koh, Choon-Sik Park
semanticscholar   +1 more source

Regular treatment with formoterol for chronic asthma: serious adverse events [PDF]

, 2012
Epidemiological evidence has suggested a link between beta(2)-agonists and increases in asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta2-agonists are safe ...
Altman, Blauw, Cates, Cates, Cates, Cates, Ducharme, Greenstone, Higgins, Lipworth, Nelson, Ni Chroinin, Ni Chroinin, Pearce, Pearce, Salpeter, Walters, Walters   +17 more
core   +1 more source

Asthma in elite athletes: Who cares? [PDF]

, 2014
Asthma or exercise-induced bronchoconstriction (EIB) is highly prevalent in athletes and if untreated has the potential to impact on their health and performance.
Hull, JH, Price, OJ
core   +1 more source

Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice [PDF]

, 2007
We have recently demonstrated that naphthoquinone (NQ), one of extractable chemical compounds of diesel exhaust particles (DEP), enhances antigen-related airway inflammation with goblet cell hyperplasia in mice (Inoue et al.
Cho Arthur K., Hiyoshi Kyoko, Ichinose Takamichi, Inoue Ken-ichiro, Kumagai Yoshito, Sakurai Miho, Sumi Daigo, Takano Hirohisa, Tomura Shigeo, Yanagisawa Rie, 井上 健一郎, 角 大悟   +11 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source