Results 41 to 50 of about 3,643,521 (182)

Associations Between Different Eosinophil Activity Markers and Clinical Outcomes in Young Asthmatics

Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.
ABSTRACT Background Identifying biomarkers for different aspects of asthma morbidity is crucial for effective disease monitoring and management. The performance of fractional exhaled nitric oxide (FeNO), blood eosinophil count (BEC), and eosinophil activity markers should be evaluated. Objective This study aimed to compare the associations of FeNO, BEC,
Nils Oskar Jõgi, Nikolaos Tsolakis, Anders Sjölander, Robert Movérare, Christer Janson, Andrei Malinovschi, Kjell Alving   +6 more
wiley   +1 more source

Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics [PDF]

, 2006
Background: Cysteinyl-leukotrienes are lipid derived mediators involved in asthma. They are able to stimulate eosinophil chemotaxis in vitro. Induced sputum from asthmatics has been shown to contain eosinophil chemotactic activity.
Bousquet, Brightling, Dent, Dworski, Green, Hatzelmann, Laitinen, Leckie, Louis, Louis, Louis, Luijk, Pavord, Romagnoli, Spada, Spanevello, Venge, Yoo   +17 more
core   +1 more source

Polydatin Relieves Airway Remodeling by Inhibiting P2X7R–NLRP3‐Mediated Excessive Autophagy in Asthma

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Background Asthma is characterized by chronic airway inflammation and remodeling. Polydatin (PD), a natural compound, has shown anti‐inflammatory potential, but its role in asthma‐related airway remodeling and the underlying mechanisms involving the P2X7R–NLRP3 inflammasome axis and autophagy remain unclear.
Guangxing Li, Liangchang Li, Zhiguang Wang, Yihua Piao, Yilan Song, Li Li, Chang Xu, Xiaowan Li, Guanghai Yan   +8 more
wiley   +1 more source

The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Allergy, Volume 81, Issue 4, Page 1173-1192, April 2026.
Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius   +16 more
wiley   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations

Allergy, Volume 81, Issue 4, Page 1124-1137, April 2026.
LAR patients who respond to AIT during the first year and are treated for two more years continue improving (less symptoms and medication intake) during the following seven years. AIT prevents the onset of asthma and allergic sensitizations in responder LAR individuals during the seven years following discontinuation.
Almudena Testera‐Montes, Laura Zubiaga‐Fernandez, Carlos J. Aranda, Irene Garcia‐Esteban, Trinidad Ilda Gaitan‐Nievas, Dulce Sanchez‐Torralvo, Cristobalina Mayorga, Maria J. Torres, Ibon Eguiluz‐Gracia, Carmen Rondon   +9 more
wiley   +1 more source

Active Principles of Tetradenia riparia; II. Antispasmodic Activity of 8(14), 15-Sandaracopimaradiene-7α, 18-diol [PDF]

, 1987
Tetradenia riparia is one of the most popular medicinal plants in Rwanda. Previously, several new substances have been isolated from the leaves, including a new diterpenediol, i.e. 8(14),15-sandaracopimaradiene-7α,18-diol. This new diterpenediol exhibits
De Kimpe, Norbert, Lefebvre, Romain, Mugabo, Pierre, Schamp, Niceas, Van Puyvelde, Luc   +4 more
core   +1 more source

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, Volume 81, Issue 4, Page 1000-1023, April 2026.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma

BMC Pulmonary Medicine, 2014
BackgroundInhaled allergen challenge is a standard method to study airway responses to inflammatory provocation and evaluate the therapeutic potential of novel anti-inflammatory compounds in asthma.
B. Leaker, Dave Singh, F. Ali, P. Barnes, B. O’connor   +4 more
semanticscholar   +1 more source

Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
Jens Tidemandsen, Anne Sophie Homøe, Peter G. Gibson, Howraman Meteran, Kasper Aanæs, Morten Hostrup, Marie Høxbro, Vibeke Backer   +7 more
wiley   +1 more source