Differential Impacts of Methadone and Buprenorphine/Naloxone on Pain-Related Outcomes Among People With Non-Heroin Opioid Use Disorder: Secondary Analyses From a Pragmatic Canadian Multisite Trial. [PDF]
Drug Alcohol RevLyman K +5 more
europepmc +1 more source
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans
Experimental Physiology, EarlyView.Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin +8 more
wiley +1 more source
Methadone-Associated Delirium in Oncology and Palliative Care: A Clinical Perspective. [PDF]
CureusShanbhag NM, Araki M.
europepmc +1 more source
Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
Efficient engagement: opportunities for mobile methadone maintenance in geographically underserved areas. [PDF]
Health Care Manag SciBonifonte A, Garcia E, Soth S, Ngo H.
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
Case Report: Reintroduction of winged infusion sets to needle syringe programs - advancing equity in harm reduction. [PDF]
Front PsychiatryJames C +9 more
europepmc +1 more source
Management of Pain in the Intensive Care Unit: A Nordic Survey
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.ABSTRACT Background Pain is common in intensive care unit (ICU) patients with up to one‐third experiencing pain at rest and even more during mobilization and clinical procedures. This survey aimed to explore physicians' attitudes and preferences regarding pain management in adult ICU patients in the Nordic countries.
Benedikte Kollerup Madsen +37 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2624-2635, August 2026.Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins +23 more
wiley +1 more source