Results 141 to 150 of about 89,531 (280)
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans
Experimental Physiology, EarlyView.Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin +8 more
wiley +1 more source
Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
Veterinary Record, Volume 198, Issue 9, Page e404-e411, 2/9 May 2026.Background This study measured serum biomarkers at baseline and during an ovariohysterectomy in healthy female Spanish greyhounds, aiming to enhance the objectivity of current methods for assessing acute postoperative pain in dogs. Methods Blood samples from 20 Spanish greyhounds were collected before drug administration (T0‐baseline).
Rocio Navarrete‐Calvo +8 more
wiley +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Family protective service involvement and reduced infant cortical grey matter volume
Infant Mental Health Journal: Infancy and Early Childhood, Volume 47, Issue 3, May 2026.Abstract Among older children, neglect is linked to reduced cortical grey matter volume, whereas abuse is linked to reduced right amygdala volume. Less is known about whether similar effects of adversity are evident in infancy, a period of particularly rapid brain growth.
Francesca Penner +4 more
wiley +1 more source
Inpatient Opioid Use in Head and Neck Microvascular Free Flap Reconstruction
Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1230-1235, May 2026.Abstract Objectives The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary aims include evaluating the impact of a multimodal analgesia (MMA) protocol and COVID‐19 visitor ...
Patricia Timothee +8 more
wiley +1 more source
Protocol of a randomised controlled trial: comparing the safety and efficacy of two methadone conversion strategies in Chinese patients with cancer pain receiving high-dose opioids. [PDF]
BMJ OpenZhou Q +5 more
europepmc +1 more source
The EUROmediCAT Network and Databases: A Resource for Pharmacovigilance in Pregnancy
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.ABSTRACT Background The evidence gap relating to the risk of congenital anomalies (CA) associated with first trimester medication exposure in pregnancy is well recognized. Aims We describe the EUROmediCAT network and databases, and the methodological approach to pregnancy pharmacovigilance.
Helen Dolk +27 more
wiley +1 more source