Results 141 to 150 of about 58,733 (293)
Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
Psychometric Properties of the Choosing Wisely Questions in a Large Psychiatric Sample
International Journal of Methods in Psychiatric Research, Volume 35, Issue 4, December 2026.ABSTRACT Objectives The Choosing Wisely Questions (CWQ) support shared decision‐making and aim to reduce low‐value care, but their psychometric properties remain unclear. This study evaluated the structural validity, reliability, and item characteristics of the Swedish CWQ in a psychiatric sample.
Johan Bengtsson +6 more
wiley +1 more source
The Effect of Opioid Abatement Funds on the Utilization of Medications for Opioid Use Disorder
Health Services Research, Volume 61, Issue 6, December 2026.ABSTRACT Objective To evaluate whether opioid abatement fund allocations to treatment programs influence the utilization of medications for opioid use disorder (MOUD). Study Setting and Design The study employed a synthetic difference‐in‐differences design and a triple‐differences model using a state‐year panel to estimate the effects of abatement fund
Jiajing Scarlette Shi, Hefei Wen
wiley +1 more source
40% rise in methadone clients over the decade.
, 2014 In excess of 9,500 clients received methadone maintenance treatment in 2013 — an increase of almost 40 per cent from levels in 2003 when the programme commenced, IMT reports.
Mudiwa, Lloyd
core
British Journal of Pharmacology, Volume 183, Issue 23, Page 6787-6800, December 2026.Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock +9 more
wiley +1 more source
In silico modeling of methadone-related ion current effects to predict QT interval prolongation. [PDF]
J Pharmacokinet PharmacodynLindsey JA +5 more
europepmc +1 more source
Scandinavian Journal of Caring Sciences, Volume 40, Issue 4, December 2026.ABSTRACT Aim To analyse the use of opioids in children with cancer and the experiences of their family members regarding opioids used in pain management to improve family nursing. Design An integrative review. Methods A systematic literature search was carried out in four databases (CINAHL, MEDLINE, PsycInfo and Scopus) in August 2023, and was ...
Noora Puusa +3 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 11, Page 1407-1417, November 2026.A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki +10 more
wiley +1 more source