Results 121 to 130 of about 51,765 (292)

A Case Report of Neuroleptic Malignant Syndrome during Methadone Therapy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2022
Background and Objective: Methadone is an opioid agonist used for the treatment of addiction to opioid drugs. Toxic leukoencephalopathy can cause serious problem and even be life-threatening.
MJ Nasr, AH Zohrevand, D Hosseini Talari, A Alizadeh Khatir   +3 more
doaj  

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Limits to methadone prescription proposed by UK drugs agency. [PDF]

, 2010
Strict limits on how long drug addicts are allowed to stay on heroin substitute methadone have been proposed by the government body responsible for treatment strategy, in what will be seen as a watershed in UK drugs policy.
Brindle, David
core  

Effect of Methadone therapy on QTc interval in electrocardiogram of opioid addicted patients

مجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Methadone is a synthetic opioid which is used in opium addiction therapy and relief of acute and chronic pain. Side effects of Methadone were reported on heart and induction of Torsade De Pointes disease and increase QTc ...
Shakouri H, Zerehsaz MJ, Farajipour S, Salehi A, Salari H, Mohammadkhani M   +5 more
doaj  

Patient and Prescriber characteristics associated with return to daily-dispense methadone: A multilevel cohort study.

PLOS Mental Health
Early in the SARS-Cov-2 pandemic, modified clinical guidance recommended the provision of take-home methadone doses for those previously ineligible to facilitate social distancing.
Ria Garg, Shaleesa Ledlie, Daniel McCormack, Nikki Bozinoff, Jennifer Wyman, Beth Sproule, Pamela Leece, Mina Tadrous, Ashley Smoke, Charlotte Munro, Tara Gomes   +10 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report

Case Reports in Pediatrics
Methadone is a synthetic opioid used to treat pain and opioid dependence. Despite its benefits, accidental ingestion of methadone in pediatric patients can lead to significant morbidity and mortality.
Jessie Pappin, Greg Hansen, Tanya Holt
doaj   +1 more source

Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use

Journal of Research in Pharmacy Practice
Objective: Given the prevalence of methadone poisoning, this study was conducted to compare the cardiovascular complications following acute methadone poisoning in patients with and without a history of long-term methadone use.
Gholamali Dorooshi, Mahbod Shirmohammadi, Farzad Gheshlaghi, Arman Otroshi, Shafeajafar Zoofaghari, Nastaran Eizadi-Mood   +5 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Inhibition of kynurenine 3‐monooxygenase (KMO) reduces fentanyl and sucrose intake and relapse‐like behaviour in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle, Lluna Careaga, Stefanie Malan‐Müller, Álvaro del Río‐García, Yaiza Trueba, Leticia Gil de Biedma‐Elduayen, Nuria Morales‐Puerto, Rebeca Vidal, Åsa Wiman, Sophie Erhardt, María Dolores Gutiérrez‐López, Esther O'Shea, María Isabel Colado   +12 more
wiley   +1 more source