Methadone - Open Access .click

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Methadone-involved overdose deaths in urban and rural communities before and after the public health emergency flexibilities for methadone take-home doses

Drug and Alcohol Dependence Reports
Background: To mitigate COVID-19 exposure risks in methadone clinics, the Substance Abuse and Mental Health Services Administration (SAMHSA) issued a temporary modification of regulations in March 2020 to permit extended take-home methadone doses: up to ...
Rebecca Arden Harris +5 more
doaj +1 more source

Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone

International Journal of Cell Biology, 2012
Previously, we have shown that SH-SY5Y cells exposed to high concentrations of methadone died due to a necrotic-like cell death mechanism related to delayed calcium deregulation (DCD).
Sergio Perez-Alvarez +7 more
doaj +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson +13 more
wiley +1 more source

Comparative effectiveness of alternative times to opioid agonist treatment taper initiation on taper completion and all‐cause mortality among people with opioid use disorder: A retrospective population‐based target trial emulation study in British Columbia, Canada, 2010–2020

Addiction, EarlyView.
Abstract Background and aims Opioid use disorder (OUD) treatment guidelines worldwide recommend opioid agonist treatment (OAT) as a long‐term, potentially indefinite treatment for managing OUD. However, many individuals express a strong interest in eventually tapering fully off treatment.
Ruyu Yan +13 more
wiley +1 more source

'I overdosed twice in two days to get methadone': A drug user on trying to get clean. [PDF]

, 2016
Heroin users in Galway are intentionally overdosing in an attempt to fast-track their access to methadone.....
Ryan, Orla
core

Factors associated with the percentage of individuals who initiate and discontinue naltrexone as a relapse prevention pharmacotherapy in opioid use disorder: A systematic review, meta‐analysis and meta‐regression

Addiction, EarlyView.
Abstract Background and aims Naltrexone is a pharmacotherapeutic option for relapse prevention in opioid use disorder (OUD); however, studies highlight low rates of initiation and high rates of discontinuation as limiting its effectiveness. We aimed to (1) estimate the percentage of individuals with OUD who (having undergone withdrawal and wish to ...
Emmert Roberts +5 more
wiley +1 more source

Development of a new synthetic process for the synthesis of (S)-methadone and (S)- and (R)-isomethadone as NMDA receptor antagonists for the treatment of depression. [PDF]

, 2023
reservedCirca 280 milioni di persone nel mondo soffrono di depressione, un disturbo mentale molto comune caratterizzato da sentimenti persistenti di tristezza, perdita di interesse o piacere nelle attività e una serie di altri sintomi emotivi e fisici ...
FABRIS, LAURA
core

A latent class analysis of clinical complexity: Secondary analysis of the collaboration leading to addiction treatment and recovery from other stresses (CLARO) randomized trial

Addiction, EarlyView.
Abstract Background and aims Individuals with opioid use disorder (OUD) frequently present with co‐occurring mental health conditions such as depression and posttraumatic stress disorder (PTSD), along with other mental health substance use disorders, physical health conditions and social determinants that together comprise ‘clinical complexity ...
Megan S. Schuler +7 more
wiley +1 more source

Methadone use 'brings stability', study finds. [PDF]

, 2018
The first-ever study in Ireland on long-term participants in methadone maintenance treatment has found that while it can bring some stability to users, more supports are needed to allow for social reintegration.
Baker, Noel
core

Death Attributed to Methadone

Pharmacopsychiatry, 2001
Besides its other effects, MMT (methadone maintenance treatment) reduces the high mortality of intravenous heroin addicts to about 30% of controls. On the other hand, deaths of patients and non-patients have been attributed to methadone. Here, we will report on the major reasons for deaths attributed to methadone and discuss suggestions for their ...
Vormfelde, Stefan Viktor, Poser, Wolfgang +1 more
openaire +3 more sources

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