Results 101 to 110 of about 51,637 (307)

Image6_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG

Acute lymphoblastic leukemia (ALL) is a hematologic cancer that mostly affects children. It accounts for over a quarter of ALL pediatric cancers, causing most of the cancer death among children.
Ki-Young Lee (185268), Hamza Kamran (18433152), Jung Kwon Lee (15149122)   +2 more
core   +1 more source

Multimorbidity in patients enrolled in a community-based methadone maintenance treatment programme delivered through primary care

, 2014
Background: Multimorbidity, the co-existence of two or more (2+) long-term conditions in an individual, is common among problem drug abusers. Objective: To delineate the patterns, multimorbidity prevalence, and disease severity in patients enrolled in a ...
Diane E. Arnold-Reed, Lakkhina Troeung, Bulsara, Max K., Jasmine O'Neill, Max K. Bulsara, Arnold-Reed, Diane E., Backhouse, Rupert, Tom Brett, Brett, Tom, Troeung, Lakkhina, Rupert Backhouse, O'Neill, Jasmine   +11 more
core   +1 more source

Barriers and facilitators to detoxification from opioid substitution treatment: A mixed‐methods systematic review

Addiction, EarlyView.
Abstract Background and aims Despite the well‐documented benefits of opioid substitution treatment (OST) in treating opioid dependence (OD), many people diagnosed with OD desire to live a drug‐free life. The transition to abstinence involves detoxification: a gradual dose reduction of OST to zero milligrams.
Amy Bagshaw, Suleyman Shah, India Olchefske, Louise M. Paterson, Mike J. Crawford, Anne Lingford‐Hughes   +5 more
wiley   +1 more source

40% rise in methadone clients over the decade.

, 2014
In excess of 9,500 clients received methadone maintenance treatment in 2013 — an increase of almost 40 per cent from levels in 2003 when the programme commenced, IMT reports.
Mudiwa, Lloyd
core  

Image4_PKA inhibition is a central step in D,L-methadone-induced ER Ca2+ release and subsequent apoptosis in acute lymphoblastic leukemia.JPEG

Acute lymphoblastic leukemia (ALL) is a hematologic cancer that mostly affects children. It accounts for over a quarter of ALL pediatric cancers, causing most of the cancer death among children.
Ki-Young Lee (185268), Hamza Kamran (18433152), Jung Kwon Lee (15149122)   +2 more
core   +1 more source

National opioid pharmacotherapy statistics annual data collection 2012 [PDF]

, 2013
On a snapshot day in 2012, almost 47,000 clients received pharmacotherapy treatment for their opioid dependence at 2,226 dosing points around Australia, this report finds.SummaryAlmost 47,000 Australians received pharmacotherapy treatment for their ...

core  

Comparative effectiveness of alternative times to opioid agonist treatment taper initiation on taper completion and all‐cause mortality among people with opioid use disorder: A retrospective population‐based target trial emulation study in British Columbia, Canada, 2010–2020

Addiction, EarlyView.
Abstract Background and aims Opioid use disorder (OUD) treatment guidelines worldwide recommend opioid agonist treatment (OAT) as a long‐term, potentially indefinite treatment for managing OUD. However, many individuals express a strong interest in eventually tapering fully off treatment.
Ruyu Yan, Jeong Eun Min, Megan Kurz, Shaun R. Seaman, Paxton Bach, Sander Greenland, Paul Gustafson, Mohammad Ehsanul Karim, Lawrence McCandless, Robert William Platt, Uwe Siebert, María Eugenia Socías, Hui Xie, Bohdan Nosyk   +13 more
wiley   +1 more source

Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?.

Methadone is increasingly involved in drug overdose cases and the molecular actions of the drug in vivo are largely unknown requiring elucidation. This study set out to examine the relationship between methadone toxicity and CYP2B6 and mu (μ) opioid ...
Bunten, Hannah
core  

Factors associated with the percentage of individuals who initiate and discontinue naltrexone as a relapse prevention pharmacotherapy in opioid use disorder: A systematic review, meta‐analysis and meta‐regression

Addiction, EarlyView.
Abstract Background and aims Naltrexone is a pharmacotherapeutic option for relapse prevention in opioid use disorder (OUD); however, studies highlight low rates of initiation and high rates of discontinuation as limiting its effectiveness. We aimed to (1) estimate the percentage of individuals with OUD who (having undergone withdrawal and wish to ...
Emmert Roberts, Elizabeth Sanderson, Thomas Santo Jr., Matthew Hickman, Michael Farrell, Louisa Degenhardt   +5 more
wiley   +1 more source

Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report

Case Reports in Pediatrics
Methadone is a synthetic opioid used to treat pain and opioid dependence. Despite its benefits, accidental ingestion of methadone in pediatric patients can lead to significant morbidity and mortality.
Jessie Pappin, Greg Hansen, Tanya Holt
doaj   +1 more source