Results 201 to 210 of about 51,637 (307)

Nonclinical Considerations for Support of Pregnancy and Lactation in Clinical Trials

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Background Pregnant and breastfeeding individuals remain underrepresented in clinical drug development, leaving health care providers and patients with limited data to inform treatment decisions. Current practice relies heavily on nonclinical developmental and reproductive toxicity (DART) studies in animals, while clinical trials typically ...
Dinesh Stanislaus, Christopher J. Bowman, Kimberly C. Brannen, Sarah N. Campion, Laura M. Carlson, Stephan Chalon, Anthony M. DeLise, Claudia Demarta‐Gatsi, Brian P. Enright, Wendy Halpern, Shermaine Mitchell‐Ryan, Vicki Sutherland, Karen Thacker, Kary Thompson, Belen Tornesi, Steven Van Cruchten, Ronald L. Wange, Tacey White, Connie L. Chen   +18 more
wiley   +1 more source

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi‐Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death

Clinical Cardiology, Volume 49, Issue 6, June 2026.
An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam, Mohammad Hosein Yazdanpanah, Narges Fereydouni   +2 more
wiley   +1 more source

Correction to: Intraoperative Intravenous Methadone and Postoperative Opioid Requirements in Adult Patients With Burns. [PDF]

J Burn Care Res
europepmc   +1 more source

Integrating Pharmacovigilance Data Mining and Mendelian Randomization to Identify Risk Profiles and Causal Targets of Opioid‐Induced Delirium

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Opioids like methadone and oxycodone pose a high risk for delirium, particularly in older adults and females. By integrating pharmacovigilance data and Mendelian randomization, we identify key genes (COMT, MYD88, CYP1B1) that influence delirium risk.
Xuetai Chen, Yuting Liu, Mingxuan Zhu, Xingman Chen, Fengyun Liu, Jiahao Jin, Zhiguo Jiang, Bin Qian, Feng Li   +8 more
wiley   +1 more source

Real-world effectiveness of medication-assisted treatment and psychotherapy for opioid use disorder: a national multi-health care organization analysis. [PDF]

Front Psychiatry
Graziane NM.
europepmc   +1 more source

Functional Brain Network Predictors of Abstinence Treatment Outcomes in Methamphetamine Use Disorder

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Baseline whole‐brain functional connectivity predicted 1‐year abstinence response in methamphetamine use disorder at the individual level. Multi‐level network analyses revealed distinct response‐related connectivity patterns involving control‐related circuits.
Yanyao Du, Shiqi Di, Na Luo, Wenhan Yang, Weiyang Shi, Zhengyi Yang, Ming Song, Huiting Zhang, Jun Zhang, Tianzi Jiang, Jun Liu   +10 more
wiley   +1 more source

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1466-1475, June 2026.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Pharmacometric modeling of opioid disposition in pregnancy: a systematic review of PopPK and PBPK approaches, model limitations, and future directions. [PDF]

Front Pharmacol
Zaidi SS, Abbasi MY, Ganapaneni S, Quinney SK.   +3 more
europepmc   +1 more source

City Nuisance Ordinances and Overdose Mortality

Journal of Policy Analysis and Management, Volume 45, Issue 3, Summer 2026.
ABSTRACT Nuisance ordinances are a class of municipal law that are framed as a way to reduce both police burden and unwanted behaviors such as repeated calls to 911, drug‐related activity, and disorderly conduct. This study explores the effect of nuisance ordinances on drug‐related mortality rates in Ohio and surrounding commuting zones from 1999 to ...
Ashley C. Bradford
wiley   +1 more source