Results 271 to 280 of about 104,643 (306)
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American Journal of Hospice and Palliative Medicine®, 2008
Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Methadone—Disulfiram Interaction During Methadone Maintenance
The Journal of Clinical Pharmacology, 1980In an attempt to characterize a possible drug interaction between methadone and disulfiram, 500 mg/day insulfiram was administered orally for seven days to seven subjects on methadone maintenance. Plasma methadone concentrations and urinary excretion of methadone and its pyrrolidine and pyrrolidone metabolites were measured and subjective symptoms of ...
T G, Tong, N L, Benowitz, M J, Kreek
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Disposition of methadone in methadone maintenance
Clinical Pharmacology & Therapeutics, 1975Six detoxified opiate addicts housed in a closed metabolic ward received methadone in stepwise increasing doses of 10, 20, 40, and 80 mg/day during 1 month. Four were given 14C‐methadone at the lowest dose and again at the highest dose. Of the subjects receiving radiomethadone, 2 excreted the major part of the radioactivity in urine and 2 about equally
E, Anggård +5 more
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Methadone and methadone metabolites in postmortem specimens
Forensic Science, Medicine, and Pathology, 2008We have determined drug/metabolite concentrations and ratios of methadone (METH) to two of its metabolites (EDDP, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine; and EMDP, 2-ethyl-5-methyl-3,3-diphenylpyrroline) in postmortem peripheral blood and liver tissue by liquid chromatography/tandem mass spectrometry.
Terry J, Danielson +2 more
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Diazepam and methadone interactions in methadone maintenance
Clinical Pharmacology and Therapeutics, 1984Survey study data and high rates of diazepam use/abuse in methadone maintenance suggest that acute administration of diazepam with daily methadone doses may enhance methadone effects. Acute subjective and physiologic effects of single oral doses of placebo, diazepam (20 and 40 mg), methadone (100%, 150%, and 200% of the maintenance dose), and four ...
K L, Preston +4 more
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Plasma methadone monitoring with methadone maintenance treatment
Drug and Alcohol Dependence, 1994Substantial evidence exists to support the effectiveness of methadone maintenance treatment (MMT), particularly with regard to reductions in intravenous drug use (Schuster, 1991) and crime (Bell et al., 1992); and to its safety and cost effectiveness compared to other (drug-free) alternatives (Glass, 1993).
K, Wolff, A W, Hay
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Methadone, methadone treatment and non-fatal overdose
Drug and Alcohol Dependence, 2000This paper provides a mainly qualitative investigation of the role of methadone and methadone treatment in non-fatal illicit drug overdose. During 1997 and 1998, semi-structured interviews were conducted with 33 individuals in six hospital accident and emergency departments in two Scottish cities.
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