Results 251 to 260 of about 51,637 (307)
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Diazepam and methadone interactions in methadone maintenance
Clinical Pharmacology and Therapeutics, 1984Survey study data and high rates of diazepam use/abuse in methadone maintenance suggest that acute administration of diazepam with daily methadone doses may enhance methadone effects. Acute subjective and physiologic effects of single oral doses of placebo, diazepam (20 and 40 mg), methadone (100%, 150%, and 200% of the maintenance dose), and four ...
K L, Preston +4 more
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Archives of General Psychiatry, 1973
Methadone hydrochloride produces subjective changes similar to those produced by heroin and is approximately equipotent to morphine when both are administered subcutaneously and one half as potent when administered orally. Chronically administered methadone produces sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution ...
W R, Martin +6 more
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Methadone hydrochloride produces subjective changes similar to those produced by heroin and is approximately equipotent to morphine when both are administered subcutaneously and one half as potent when administered orally. Chronically administered methadone produces sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution ...
W R, Martin +6 more
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Methadone Maintenance: A Comparison of Methadone Treatment Subjects and Methadone Treatment Dropouts
International Journal of the Addictions, 1975Commonly agreed upon goals in conjunction with methadone maintenance have been (1) a return to legitimate employment, (2) cessation or substantial reduction in criminal behavior, (3) reduction in the amount of time spent in drug-seeking behavior, (4) involvement with a social system in which there is a positive reinforcement for relating to people, and
W V, Williams, J, Lee
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BMJ, 2012
When I was young, I drank to get wrecked. In the hospitals in the 1980s and 1990s, I witnessed the complications of heroin addiction: amputations, gangrene, endocarditis, sepsis, hepatitis, and HIV. A stream of ambulances spilt half dead overdosers onto accident and emergency trolleys. There was no drug for opioid substitution—for example, methadone—so
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When I was young, I drank to get wrecked. In the hospitals in the 1980s and 1990s, I witnessed the complications of heroin addiction: amputations, gangrene, endocarditis, sepsis, hepatitis, and HIV. A stream of ambulances spilt half dead overdosers onto accident and emergency trolleys. There was no drug for opioid substitution—for example, methadone—so
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Journal of Pain & Palliative Care Pharmacotherapy, 2005
Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Ralph A, Lugo +2 more
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Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Ralph A, Lugo +2 more
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JAMA: The Journal of the American Medical Association, 1978
To the Editor.— In the course of treating patients with severe pain, it is sometimes difficult to continue administering injections of narcotic analgesics over prolonged periods for various reasons. This is especially a problem in terminally ill patients who require higher-than-usual doses or more frequent drug administration than usual.
A A, Cardoni, J K, Walters
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To the Editor.— In the course of treating patients with severe pain, it is sometimes difficult to continue administering injections of narcotic analgesics over prolonged periods for various reasons. This is especially a problem in terminally ill patients who require higher-than-usual doses or more frequent drug administration than usual.
A A, Cardoni, J K, Walters
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Annals of the New York Academy of Sciences, 1976
We have demonstrated the dangers of alcoholism that complicate methadone treatment of heroin addiction. In future papers, we will attempt to identify contributory factors and suggest interventionist techniques. In the final analysis, however, rehabilitation programs, vocational programs, and, above all, alleviation of the dreadful socioeconomic ...
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We have demonstrated the dangers of alcoholism that complicate methadone treatment of heroin addiction. In future papers, we will attempt to identify contributory factors and suggest interventionist techniques. In the final analysis, however, rehabilitation programs, vocational programs, and, above all, alleviation of the dreadful socioeconomic ...
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Hopping on the methadone bus [PDF]
Journal of Health Economics, 2009 This paper investigates the impact of a 'free drug program' on the market equilibrium of drugs. We introduce a screening model of the hard drug market in which dealers use payment and punishment options to screen between high and low risk users. We show that, if a free drug program selects sufficiently many high-risk drug users, the pure-strategy ...
Lippert, Steffen, Schumacher, Christoph
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Effects of buprenorphine and methadone in methadone-maintained subjects
Psychopharmacology, 1995Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of a program to develop procedures for
S L, Walsh +5 more
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Methadone—Disulfiram Interaction During Methadone Maintenance
The Journal of Clinical Pharmacology, 1980In an attempt to characterize a possible drug interaction between methadone and disulfiram, 500 mg/day insulfiram was administered orally for seven days to seven subjects on methadone maintenance. Plasma methadone concentrations and urinary excretion of methadone and its pyrrolidine and pyrrolidone metabolites were measured and subjective symptoms of ...
T G, Tong, N L, Benowitz, M J, Kreek
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