Results 231 to 240 of about 58,733 (293)
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American Journal of Hospice and Palliative Medicine®, 2008
Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Disposition of methadone in methadone maintenance
Clinical Pharmacology & Therapeutics, 1975Six detoxified opiate addicts housed in a closed metabolic ward received methadone in stepwise increasing doses of 10, 20, 40, and 80 mg/day during 1 month. Four were given 14C‐methadone at the lowest dose and again at the highest dose. Of the subjects receiving radiomethadone, 2 excreted the major part of the radioactivity in urine and 2 about equally
E, Anggård +5 more
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Methadone and methadone metabolites in postmortem specimens
Forensic Science, Medicine, and Pathology, 2008We have determined drug/metabolite concentrations and ratios of methadone (METH) to two of its metabolites (EDDP, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine; and EMDP, 2-ethyl-5-methyl-3,3-diphenylpyrroline) in postmortem peripheral blood and liver tissue by liquid chromatography/tandem mass spectrometry.
Terry J, Danielson +2 more
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The levels of methadone in the plasma in methadone maintenance
Clinical Pharmacology & Therapeutics, 1972The time course of methadone in the plasma of 5 methadone maintenance subjects receiving a single daily oral dose of 100 or 120 mg. has been determined. The predose mean plasma level of methadone was 0.48 fig per milliliter. The peak plasma level occurred at 4 hours with an average value of 0.86 fig per milliliter. This level slowly declined so that 24
C E, Inturrisi, K, Verebely
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Diazepam and methadone interactions in methadone maintenance
Clinical Pharmacology and Therapeutics, 1984Survey study data and high rates of diazepam use/abuse in methadone maintenance suggest that acute administration of diazepam with daily methadone doses may enhance methadone effects. Acute subjective and physiologic effects of single oral doses of placebo, diazepam (20 and 40 mg), methadone (100%, 150%, and 200% of the maintenance dose), and four ...
K L, Preston +4 more
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Archives of General Psychiatry, 1973
Methadone hydrochloride produces subjective changes similar to those produced by heroin and is approximately equipotent to morphine when both are administered subcutaneously and one half as potent when administered orally. Chronically administered methadone produces sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution ...
W R, Martin +6 more
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Methadone hydrochloride produces subjective changes similar to those produced by heroin and is approximately equipotent to morphine when both are administered subcutaneously and one half as potent when administered orally. Chronically administered methadone produces sedation, lethargic apathy, reduction in sexual interest and activity, hemodilution ...
W R, Martin +6 more
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Methadone Maintenance: A Comparison of Methadone Treatment Subjects and Methadone Treatment Dropouts
International Journal of the Addictions, 1975Commonly agreed upon goals in conjunction with methadone maintenance have been (1) a return to legitimate employment, (2) cessation or substantial reduction in criminal behavior, (3) reduction in the amount of time spent in drug-seeking behavior, (4) involvement with a social system in which there is a positive reinforcement for relating to people, and
W V, Williams, J, Lee
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BMJ, 2012
When I was young, I drank to get wrecked. In the hospitals in the 1980s and 1990s, I witnessed the complications of heroin addiction: amputations, gangrene, endocarditis, sepsis, hepatitis, and HIV. A stream of ambulances spilt half dead overdosers onto accident and emergency trolleys. There was no drug for opioid substitution—for example, methadone—so
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When I was young, I drank to get wrecked. In the hospitals in the 1980s and 1990s, I witnessed the complications of heroin addiction: amputations, gangrene, endocarditis, sepsis, hepatitis, and HIV. A stream of ambulances spilt half dead overdosers onto accident and emergency trolleys. There was no drug for opioid substitution—for example, methadone—so
openaire +2 more sources