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Temporal trends in outcomes for infants with neonatal opioid withdrawal managed with the Finnegan scoring tool: Insights from the INFORM NOW Study. [PDF]
Devlin LA +14 more
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Travel Time to Methadone Treatment Via Personal Vehicle vs Public Transit.
Howell BA +8 more
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Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching from an opioid to methadone or vice versa requires knowledge of equianalgesic dosing.
Chhabra, Shalini, Bull, Janet
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Disposition of methadone in methadone maintenance
Clinical Pharmacology & Therapeutics, 1975Six detoxified opiate addicts housed in a closed metabolic ward received methadone in stepwise increasing doses of 10, 20, 40, and 80 mg/day during 1 month. Four were given 14C‐methadone at the lowest dose and again at the highest dose. Of the subjects receiving radiomethadone, 2 excreted the major part of the radioactivity in urine and 2 about equally
E, Anggård +5 more
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Methadone and methadone metabolites in postmortem specimens
Forensic Science, Medicine, and Pathology, 2008We have determined drug/metabolite concentrations and ratios of methadone (METH) to two of its metabolites (EDDP, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine; and EMDP, 2-ethyl-5-methyl-3,3-diphenylpyrroline) in postmortem peripheral blood and liver tissue by liquid chromatography/tandem mass spectrometry.
Terry J, Danielson +2 more
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The levels of methadone in the plasma in methadone maintenance
Clinical Pharmacology & Therapeutics, 1972The time course of methadone in the plasma of 5 methadone maintenance subjects receiving a single daily oral dose of 100 or 120 mg. has been determined. The predose mean plasma level of methadone was 0.48 fig per milliliter. The peak plasma level occurred at 4 hours with an average value of 0.86 fig per milliliter. This level slowly declined so that 24
C E, Inturrisi, K, Verebely
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