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Journal of Pain & Palliative Care Pharmacotherapy, 2005
Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Ralph A, Lugo +2 more
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Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence. The pharmacokinetics of methadone differ from those of morphine in that methadone has a higher bioavailability, a much longer half-life, and is hepatically metabolized by cytochrome P450 enzymes.
Ralph A, Lugo +2 more
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JAMA: The Journal of the American Medical Association, 1978
To the Editor.— In the course of treating patients with severe pain, it is sometimes difficult to continue administering injections of narcotic analgesics over prolonged periods for various reasons. This is especially a problem in terminally ill patients who require higher-than-usual doses or more frequent drug administration than usual.
A A, Cardoni, J K, Walters
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To the Editor.— In the course of treating patients with severe pain, it is sometimes difficult to continue administering injections of narcotic analgesics over prolonged periods for various reasons. This is especially a problem in terminally ill patients who require higher-than-usual doses or more frequent drug administration than usual.
A A, Cardoni, J K, Walters
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Annals of the New York Academy of Sciences, 1976
We have demonstrated the dangers of alcoholism that complicate methadone treatment of heroin addiction. In future papers, we will attempt to identify contributory factors and suggest interventionist techniques. In the final analysis, however, rehabilitation programs, vocational programs, and, above all, alleviation of the dreadful socioeconomic ...
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We have demonstrated the dangers of alcoholism that complicate methadone treatment of heroin addiction. In future papers, we will attempt to identify contributory factors and suggest interventionist techniques. In the final analysis, however, rehabilitation programs, vocational programs, and, above all, alleviation of the dreadful socioeconomic ...
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Hopping on the methadone bus [PDF]
Journal of Health Economics, 2009 This paper investigates the impact of a 'free drug program' on the market equilibrium of drugs. We introduce a screening model of the hard drug market in which dealers use payment and punishment options to screen between high and low risk users. We show that, if a free drug program selects sufficiently many high-risk drug users, the pure-strategy ...
Lippert, Steffen, Schumacher, Christoph
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Effects of buprenorphine and methadone in methadone-maintained subjects
Psychopharmacology, 1995Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of a program to develop procedures for
S L, Walsh +5 more
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Pediatrics, 1971
The increasing use of methadone maintenance (substitution) programs1-3 in the treatment of adult heroin addiction has created situations for children which require the attention of pediatricians. Methadone is an analgesic drug. In urban areas, thousands of heroin addicts are now receiving high dosage of methadone, usually 80 to 120 mg daily.
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The increasing use of methadone maintenance (substitution) programs1-3 in the treatment of adult heroin addiction has created situations for children which require the attention of pediatricians. Methadone is an analgesic drug. In urban areas, thousands of heroin addicts are now receiving high dosage of methadone, usually 80 to 120 mg daily.
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Methadone—Disulfiram Interaction During Methadone Maintenance
The Journal of Clinical Pharmacology, 1980In an attempt to characterize a possible drug interaction between methadone and disulfiram, 500 mg/day insulfiram was administered orally for seven days to seven subjects on methadone maintenance. Plasma methadone concentrations and urinary excretion of methadone and its pyrrolidine and pyrrolidone metabolites were measured and subjective symptoms of ...
T G, Tong, N L, Benowitz, M J, Kreek
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Plasma methadone monitoring with methadone maintenance treatment
Drug and Alcohol Dependence, 1994Substantial evidence exists to support the effectiveness of methadone maintenance treatment (MMT), particularly with regard to reductions in intravenous drug use (Schuster, 1991) and crime (Bell et al., 1992); and to its safety and cost effectiveness compared to other (drug-free) alternatives (Glass, 1993).
K, Wolff, A W, Hay
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Annals of Internal Medicine, 1973
Excerpt To the editor: The case of a patient recently seen by us is pertinent to the methadone-Tang® problem described in a letter that appeared in the May 1972 issue (p. 830).
A M, Smith, M B, Dratch, S S, Mintz
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Excerpt To the editor: The case of a patient recently seen by us is pertinent to the methadone-Tang® problem described in a letter that appeared in the May 1972 issue (p. 830).
A M, Smith, M B, Dratch, S S, Mintz
openaire +2 more sources