Results 111 to 120 of about 37,401 (251)

FAIRly deferred: Low impact of the individualised risk assessment policy on blood donor deferrals in England

open access: yesTransfusion Medicine, EarlyView.
Abstract Objectives To assess the impact of the individualised risk‐based donor selection guidelines on deferral of blood donors at donation sessions in England. Background From June 2021, the 3‐month deferral for sex between men was replaced by an individualised risk assessment known as FAIR (For the Assessment of Individualised Risk).
Katherine Daly   +3 more
wiley   +1 more source

Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans

open access: yesExperimental Physiology, EarlyView.
Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin   +8 more
wiley   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto   +7 more
wiley   +1 more source

Sex‐Modulated TACSTD2 Methylation and Hormone‐Receptor Axis Interactions in Glioblastoma: Insights Toward Mechanistic Understanding

open access: yesComputational and Systems Oncology, Volume 6, Issue 1, December 2026.
Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley   +1 more source

Locomotor and discriminative stimulus effects of N-cyclohexyl butylone and N-cyclohexyl methylone. [PDF]

open access: yesFront Pharmacol
Gatch MB   +5 more
europepmc   +1 more source

“It Was Like They'd Lit a Fuse”: A Mixed‐Methods Investigation Into Rage

open access: yesAggressive Behavior, Volume 52, Issue 4, July 2026.
ABSTRACT Impulsive acts of violence are perpetrated by a small proportion of society, which anecdotal evidence suggests often occurs in a rage state. Rage has generally been conceptualized as extreme anger, but it may be qualitatively different from extreme anger.
Thomas F. Denson   +5 more
wiley   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

open access: yesChirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz   +1 more
wiley   +1 more source

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