Results 41 to 50 of about 110,845 (343)

Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence. [PDF]

, 2009
Despite the worldwide extent of methamphetamine dependence, no medication has been shown to effectively treat afflicted individuals. One relatively unexplored approach is modulation of cholinergic system function.
Clement, Clayton, De La Garza, Richard, London, Edythe D, Miotto, Karen, Newton, Thomas F, Sevak, Rajkumar J, Shoptaw, Steven, Swanson, Aimee-Noelle, Zorick, Todd   +8 more
core  

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

A mindfulness-based, stress and coping model of craving in methamphetamine users.

PLoS ONE, 2021
There is increasing interest in the role of mindfulness and mindfulness-based interventions to optimize recovery from a substance use disorder (SUD). However, relatively little is known about the theory-based psychological and social pathways whereby ...
Massy Mutumba, Judith T Moskowitz, Torsten B Neilands, Ji-Young Lee, Samantha E Dilworth, Adam W Carrico   +5 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin [PDF]

, 2018
Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase ...
Baucum, Anthony J., II, Edler, Michael C., Kaur, Harjot, Morris, Cameron W., Salek, Asma B., Watkins, Darryl S., Yamamoto, Bryan K.   +6 more
core   +1 more source

A community‐driven approach to address substance use and create a Great Plains American Indian addiction and recovery research agenda

American Journal of Community Psychology, EarlyView.
Abstract Substance use, specifically opioid and methamphetamine use, is of increasing concern among American Indian (AI) populations in the Great Plains. This community‐driven participatory study investigated the impacts of substance use and community‐defined needs in treating addiction.
Brynn Luger, Anna Kihlström, Brinda Sivaramakrishnan, Allison Kelliher, Frankie Kropp, Carmen Rosa, T. John Winhusen, Donald Warne, the CTN0129 participating Tribal communities   +8 more
wiley   +1 more source

Methamphetamine-mediated astrocytic pyroptosis and neuroinflammation involves miR-152–NLRP6 inflammasome signaling axis

Redox Biology
Methamphetamine is a widely abused drug associated with significant neuroinflammation and neurodegeneration, mainly through the activation of glial cells and neurons in the central nervous system.
Abiola Oladapo, Muthukumar Kannan, Uma Maheswari Deshetty, Seema Singh, Shilpa Buch, Palsamy Periyasamy   +5 more
doaj   +1 more source

Methamphetamine-Related Disorders [PDF]

Deutsches Ärzteblatt international, 2017
Methamphetamine is considered more dangerous than other stimulants because of its acute complications, long-term neurotoxicity, and potential for drug dependence. Until now, there have been no evidence-based guidelines for the treatment of methamphetamine-related disorders, either in Germany or abroad.A systematic literature search was performed on the
Gouzoulis-Mayfrank, Euphrosyne, Härtel-Petri, Roland, Hamdorf, Willem, Havemann-Reinecke, Ursula, Mühlig, Stephan, Wodarz, Norbert   +5 more
openaire   +3 more sources

A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice. [PDF]

, 2020
Methamphetamine (MA) and alcohol use disorders exhibit a high degree of co-morbidity and sequential alcohol-MA mixing increases risk for co-abuse. Recently, we reported greater MA-conditioned reward in male C57BL/6J mice with a prior history of binge ...
Bryant, Camron D, Coelho, Michal A, Fultz, Elissa K, Sern, Kimberly R, Szumlinski, Karen K   +4 more
core   +1 more source

Men and women from the STRIDE clinical trial: An assessment of stimulant abstinence symptom severity at residential treatment entry [PDF]

, 2015
Background and Objectives Gender‐specific factors associated with stimulant abstinence severity were examined in a stimulant abusing or dependent residential treatment sample (N = 302).
Burrow, Allison, Carmody, Thomas, Chartier, Karen G., Greer, Tracy L., Killeen, Therese K., Sanchez, Katherine, Trivedi, Madhukar H.   +6 more
core   +2 more sources