Results 51 to 60 of about 707,147 (312)
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Nachrichten aus der Chemie, 2020 AbstractBisher gab es keine praktikable Methode, eine Methanolvergiftung in Minutenschnelle zu diagnostizieren. Ein kürzlich entwickelter Gassensor erlaubt dies nun mit einem einzigen Atemstoß. Der Detektor passt auf eine Handfläche und erkennt Methanol auch in gepanschtem Schnaps.
van den Broek, Jan, Güntner, Andreas
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Febuxostat methanol solvate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2011 In the title compound {systematic name: [2-(3-cyano-4-isobutyl-oxyphen-yl)-4-methyl-1,3-thia-zole-5-carb-oxy-lic acid (febuxostat) methanol monosolvate}, C(16)H(16)N(2)O(3)S·CH(4)O, the benzene and thia-zole rings in the febuxostat mol-ecule are twisted at 5.3 (1)°.
Xiu-Rong Hu +4 more
openaire +4 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Energies, 2019 Methanol and ethanol are among the most important biofuels and raw materials used to produce biorenewable fuels. These fuels are used with varying water contents.
Jozef Martinka +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Energies, 2009 Solid oxide fuel cells (SOFC) have the advantage of being able to operate with fuels other than hydrogen. In particular, liquid fuels are especially attractive for powering portable applications such as small power generators or auxiliary power units, in
Massimiliano Cimenti, Josephine M. Hill
doaj +1 more source
Exchange of Deuterium Between Methanol and Water: Vibrations of the Hydroxyl Group in Methanol and Methanol-d: The Entropy of Methanol [PDF]
The Journal of Chemical Physics, 1938 New measurements of the equilibrium in the exchange reaction between methanol and heavy water, in conjunction with data in the literature, are considered in relation to the vibrations of the hydroxyl group, including the torsional degree of freedom.
Halford, J. O., Pecherer, B.
openaire +3 more sources
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source