Results 71 to 80 of about 1,457,583 (292)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Product Protection, the Key to Developing High Performance Methane Selective Oxidation Catalysts [PDF]

, 2009
Selective, direct conversion of methane to methanol might seem an impossible task since the C−H bond energy of methane is 105 kcal mol^(−1) compared to the C−H bond energy for methanol of 94.
Ahlquist, Mårten, Goddard, William A., III, Nielsen, Robert J., Periana, Roy A.   +3 more
core   +2 more sources

VLA observations of water masers towards 6.7 GHz methanol maser sources

, 2010
22 GHz water and 6.7 GHz methanol masers are usually thought as signposts of early stages of high-mass star formation but little is known about their associations and the physical environments they occur in. The aim was to obtain accurate positions and
A. Bartkiewicz, A. Brunthaler, Bartkiewicz, Bartkiewicz, Brunthaler, Beuther, Brand, Breen, Breen, Caswell, Cragg, Cyganowski, Cyganowski, Davis, De Buizer, De Buizer, Dodson, Elitzur, Fazio, H. J. van Langevelde, M. J. Reid, M. Szymczak, McCaughrean, Menten, Minier, Moscadelli, Moscadelli, Norris, Palla, Pestalozzi, Philips, Pillai, Reid, Rygl, Smith, Sridharan, Szymczak, Szymczak, Szymczak, Urquhart, van der Walt, van der Walt, Walsh, Xu, Y. M. Pihlström   +43 more
core   +1 more source

Methanol and isopropanol embryo dosage response curves for wild-type and ethanol-sensitive zebrafish [PDF]

, 2016
It is well established that ethanol has an array of negative effects on developing embryos, from craniofacial abnormalities to cognitive deficits and behavioral disorders.
Anderson, Ashley
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Visualization study on spray and ignition characteristics of high proportion methanol / PODE blended fuel

Journal of Thermal Science and Technology
With the increasingly stringent emission requirements for shipping, methanol is a promising alternative fuel. The effects of mixing ratio and ambient temperature on the spray and ignition characteristics of high proportion methanol / Polyoxymethylene ...
Rongkang SUN, Lijiang WEI, Wei SONG, Xiuwei LU, Chen HUANG   +4 more
doaj   +1 more source

Statistical properties of 12.2 GHz methanol masers associated with a complete sample of 6.7 GHz methanol masers

, 2011
We present definitive detection statistics for 12.2 GHz methanol masers towards a complete sample of 6.7 GHz methanol masers detected in the Methanol Multibeam survey south of declination -20 degrees.
A. Avison, Brand, Caswell, Caswell, Caswell, Caswell, Caswell, Catarzi, Chambers, Cyganowski, Cyganowski, Ellingsen, Ellingsen, Forster, G. A. Fuller, Gaylard, Genzel, J. A. Green, J. L. Caswell, L. J. Quinn, Lewis, M. A. Voronkov, MacLeod, Moscadelli, Pandian, Rathborne, Reid, S. L. Breen, S. P. Ellingsen, Sault, Sobolev, Walsh, Wu   +32 more
core   +1 more source

Mapping deuterated methanol toward L1544: I. Deuterium fraction and comparison with modeling [PDF]

, 2018
The study of deuteration in pre-stellar cores is important to understand the physical and chemical initial conditions in the process of star formation.
Bizzocchi, L., Caselli, P., Chacon-Tanarro, A., Giuliano, B. M., Lattanzi, V., Pineda, J. E., Punanova, A., Sipila, O., Spezzano, S., Vasyunin, A.   +9 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Herschel observations of EXtra-Ordinary Sources (HEXOS): Methanol as a probe of physical conditions in Orion KL [PDF]

, 2011
We have examined methanol emission from Orion KL withthe Herschel/HIFI instrument, and detected two methanol bands centered at 524 GHz and 1061 GHz. The 524 GHz methanol band (observed in HIFI band 1a) is dominated by the isolated ΔJ = 0, K = −4 → −3 ...
Bell, T. A., Blake, G. A., Latter, W. B., Lis, D. C., Lord, S. D., Morris, P., Phillips, T. G., Wang, S., Zmuidzinas, J.   +8 more
core