Results 61 to 70 of about 1,457,583 (292)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Distinct Crystallization Pathways of Polyoxymethylene in Methanol System

Crystals
Recrystallization of polyoxymethylene (POM) in solvent is an effective post-treatment method for manufacturing a better POM product. Herein, the crystallization process of POM in methanol was investigated with the use of a series of equipment.
Haowen Du, Xiaomeng Zhou, Yaru Zhang, Yang Ye, Shutian Xuanyuan, Sen Yang, Guorui Lao, Chuang Xie   +7 more
doaj   +1 more source

Comparative energetic assessment of methanol production from CO₂: chemical versus electrochemical process [PDF]

, 2015
Emerging emission-to-liquid (eTL) technologies that produce liquid fuels from CO₂ are a possible solution for both the global issues of greenhouse gas emissions and fossil fuel depletion.
Al-Kalbani, H, García, S, Wang, H, Xuan, J   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

KIT COLORIMÉTRICO PARA DETECÇÃO DE METANOL EM ETANOL COMBUSTÍVEL PARA O MONITORAMENTO DA QUALIDADE DE COMBUSTÍVEIS

Química Nova, 2015
A colorimetric kit for methanol detection in ethanol-containing fuels and ease of use in the field was developed and tested. The analysis can detect the presence of methanol in fuels when exceeding specification (0.5% v/v) in about 20 min and its simple ...
Guilherme B. C. Martins, Mateus A. Montenegro, Paulo A. Z. Suarez   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Methanol

Abstract Methanol is becoming more and more well-known as a low-carbon fuel, adaptable chemical feedstock, and useful energy carrier. It is a liquid with a high hydrogen concentration at room temperature. Its whole supply chain is reviewed in this chapter. In order to evaluate energy efficiency and life-cycle emissions, production methods are
Mohammed Al-Breiki, Yusuf Bicer
  +6 more sources

The Relationship between Class I and Class II Methanol Masers

, 2005
The Australia Telescope National Facility Mopra millimetre telescope has been used to search for 95.1-GHz class I methanol masers towards sixty-two 6.6-GHz class II methanol masers.
Bachiller, Batrla, Batrla, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Cragg, Crowther, De Lucia, Egan, Ellingsen, Ellingsen, Ellingsen, Genzel, Genzel, Houghton, Johnston, Kogan, Kurtz, Kutner, Lumsden, Mehringer, Menten, Menten, Minier, Morimoto, Müller, Peng, Pestalozzi, Pestalozzi, Phillips, Plambeck, Plambeck, S. P. Ellingsen, Slysh, Slysh, Sobolev, Sobolev, Szymczak, Szymczak, Val'tts, van der Walt, Voronkov, Walsh, Walsh, Walsh, Wiesemeyer, Wilson, Wilson, Wood   +55 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Improving the Cu/ZnO-Based Catalysts for Carbon Dioxide Hydrogenation to Methanol, and the Use of Methanol As a Renewable Energy Storage Media

Frontiers in Earth Science, 2020
Heterogeneous catalytic hydrogenation of carbon dioxide (CO2) to methanol is a practical approach to mitigating its greenhouse effect in the environment while generating good economic profits.
Ubong J. Etim, Yibing Song, Ziyi Zhong, Ziyi Zhong   +3 more
doaj   +1 more source