Results 61 to 70 of about 1,541,007 (326)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A new electron-methanol molecule pseudopotential and its application for the solvated electron in methanol [PDF]

, 2010
A new electron–methanol molecule pseudopotential is developed and tested in the present paper. The formal development of the potential is based on quantum mechanical calculations on the electron-methanol molecule model in the static exchange ...
Mones, Letif, Turi, László
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

12.2-GHz methanol maser MMB follow-up catalogue - II. Longitude range 186 to 330 degrees

, 2012
We present the second portion of a catalogue of 12.2-GHz methanol masers detected towards 6.7-GHz methanol masers observed in the unbiased Methanol Multibeam (MMB) Survey.
A. Avison, Breen, Breen, Breen, Breen, Błaszkiewicz, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Caswell, Catarzi, Cragg, Cragg, Cragg, Dodson, Ellingsen, Ellingsen, Ellingsen, Ellingsen, Felli, G. A. Fuller, Gaylard, Goedhart, Green, Green, Green, Green, Green, J. A. Green, J. L. Caswell, Kemball, Koo, L. J. Quinn, M. A. Voronkov, MacLeod, Minier, Moscadelli, Müller, Norris, Norris, Ott, Pandian, Reid, S. L. Breen, S. P. Ellingsen, Sutton, Szymczak, Val'tts, Voronkov, Xu   +55 more
core   +1 more source

Mapping deuterated methanol toward L1544: I. Deuterium fraction and comparison with modeling [PDF]

, 2018
The study of deuteration in pre-stellar cores is important to understand the physical and chemical initial conditions in the process of star formation.
Bizzocchi, L., Caselli, P., Chacon-Tanarro, A., Giuliano, B. M., Lattanzi, V., Pineda, J. E., Punanova, A., Sipila, O., Spezzano, S., Vasyunin, A.   +9 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The effects of methanol on the trapping of volatile ice components [PDF]

, 2015
The evaporation of icy mantles, which have been formed on the surface of dust grains, is acknowledged to give rise to the rich chemistry that has been observed in the vicinity of hot cores and corinos.
Adriaens, Ayotte, Backus, Bar-Nun, Blake, Bockelee-Morvan, Bolina, Bolina, Boogert, Brown, Burke, Burke, Codella, Collings, Cruikshank, Daren J. Burke, Dartois, De Jong, DelloRusso, Edridge, Ehrenfreund, Ehrenfreund, Fraser, Garozzo, Gibb, Goumans, Grim, Hagen, Herbst, Ioppolo, Jewitt, Klinger, Lellouch, Martín-Doménech, Merlin, Merlin, Mills, Notesco, Palumbo, Palumbo, Pontoppidan, Smith, Smith, Souda, Souda, Souda, Viti, Wendy A. Brown, Whittet, Wolff, Yung   +50 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Renewable Methanol as a Fuel for Heavy-Duty Engines: A Review of Technologies Enabling Single-Fuel Solutions

Energies
To meet climate targets, a global shift away from fossil fuels is essential. For sectors where electrification is impractical, it is crucial to find sustainable energy carriers.
Yi-Hao Pu, Quinten Dejaegere, Magnus Svensson, Sebastian Verhelst   +3 more
doaj   +1 more source

Identification of putative methanol dehydrogenase (moxF) structural genes in methylotrophs and cloning of moxF genes from Methylococcus capsulatus bath and Methylomonas albus BG8 [PDF]

, 1988
An open-reading-frame fragment of a Methylobacterium sp. strain AM1 gene (moxF) encoding a portion of the methanol dehydrogenase structural protein has been used as a hybridization probe to detect similar sequences in a variety of methylotrophic bacteria.
Haygood, Margo G., Lidstrom, Mary E., Stephens, Richard L.   +2 more
core