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Methicillin Resistant Staphylococci
JAMA: The Journal of the American Medical Association, 1971To the Editor.— Recently, O'Toole et al called attention to an outbreak of methicillin-resistantStaphylococcus aureus(213:257,1970). We have reviewed the problem of methicillin resistance at Memorial Hospital for Cancer and Allied Diseases, New York, during a six-year period ( Feb 24, 1964 to Nov 25, 1969)..
Anne Blevins +2 more
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Expression of resistance to methicillin
Trends in Microbiology, 1994Methicillin-resistant staphylococci have an additional low-affinity penicillin-binding protein, PBP2a (PBP2'), encoded by the mecA gene. The typical heterogeneity seen in the expression of resistance to methicillin and in levels of resistance depends on the concerted action of chromosomally encoded genes, including fem and aux, that are also present in
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The Lancet, 1997 Methicillin-Resistant Staphylococcus epidermidis
Southern Medical Journal, 1978Staphylococcus epidermidis is frequently associated with infection of prosthetic heart valves, prosthetic orthopedic devices, and neurosurgical shunts. Penicillinase-resistant semisynthetic penicillins, such as methicillin, have been the therapeutic and prophylactic agents of choice for S epidermidis infection.
Moreland Nj, Williams Tw, Siebert Wt
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Replicating methicillin resistance?
Nature Structural & Molecular Biology, 2016Methicillin resistance in the clinically important bacterium Staphylococcus aureus (MRSA) has evolved in multiple S. aureus lineages through acquisition of chromosomally integrating mobile genetic elements named SCCmec. Now Rice and colleagues show that the conserved SCCmec cch gene encodes an active DNA helicase, thus suggesting that extrachromosomal ...
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METHICILLIN RESISTANCE IN STAPHYLOCOCCUS AUREUS
The Lancet, 1970Abstract Two independent surveys of the frequency of methicillin resistance in Staphylococcus aureus indicate that there was a moderate increase between 1960 and 1963, followed by a stationary period. A second increase began in 1968 and is continuing. Resistant strains have been present in many hospitals for some years, and the more recent increase in
M.T. Parker, J.H. Hewitt
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Methicillin-resistant staphylococci
The American Journal of the Medical Sciences, 1972F. H. Kayser, T. M. Mak
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Methicillin-resistant staphylococcal mastitis
American Journal of Obstetrics and Gynecology, 1989A postpartum patient had a unilateral breast infection that responded to cephalosporin treatment. During therapy, the contralateral breast developed a methicillin-resistant Staphylococcus aureus infection. The patient was hospitalized and treated successfully with intravenous vancomycin.
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Mechanisms of methicillin resistance in staphylococci
APMIS, 1997The continuously high prevalence of methicillin‐resistant staphylococci (MRS) throughout the world is a constant threat to public health, owing to the multiresistant characteristics of these bacteria. Methicillin resistance is phenotypically associated with the presence of the penicillin‐binding protein 2a (PBP2a) not present in susceptible ...
Odd Gunnar Brakstad, Johan A. Maeland
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