Results 11 to 20 of about 3,608,507 (334)

Emergence of methicillin resistance predates the clinical use of antibiotics. [PDF]

Nature, 2022
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon ...
Larsen J, Raisen CL, Ba X, Sadgrove NJ, Padilla-González GF, Simmonds MSJ, Loncaric I, Kerschner H, Apfalter P, Hartl R, Deplano A, Vandendriessche S, Černá Bolfíková B, Hulva P, Arendrup MC, Hare RK, Barnadas C, Stegger M, Sieber RN, Skov RL, Petersen A, Angen Ø, Rasmussen SL, Espinosa-Gongora C, Aarestrup FM, Lindholm LJ, Nykäsenoja SM, Laurent F, Becker K, Walther B, Kehrenberg C, Cuny C, Layer F, Werner G, Witte W, Stamm I, Moroni P, Jørgensen HJ, de Lencastre H, Cercenado E, García-Garrote F, Börjesson S, Hæggman S, Perreten V, Teale CJ, Waller AS, Pichon B, Curran MD, Ellington MJ, Welch JJ, Peacock SJ, Seilly DJ, Morgan FJE, Parkhill J, Hadjirin NF, Lindsay JA, Holden MTG, Edwards GF, Foster G, Paterson GK, Didelot X, Holmes MA, Harrison EM, Larsen AR.   +63 more
europepmc   +2 more sources

Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms. [PDF]

Nat Commun, 2022
SCCmec is a large mobile genetic element that includes the mecA gene and confers resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA).
Maree M, Thi Nguyen LT, Ohniwa RL, Higashide M, Msadek T, Morikawa K.   +5 more
europepmc   +2 more sources

Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal. [PDF]

Trop Med Health, 2021
Background Staphylococcus aureus is a global public health issue in both community and hospital settings. Management of methicillin-resistant S. aureus (MRSA) infections are tough owing to its resistance to many antibiotics.
Thapa D, Pyakurel S, Thapa S, Lamsal S, Chaudhari M, Adhikari N, Shrestha D.   +6 more
europepmc   +2 more sources

An epidemiological study of the predictors of multidrug resistance and methicillin resistance among Staphylococcus spp. isolated from canine specimens submitted to a diagnostic laboratory in Tennessee, USA [PDF]

PeerJ, 2023
Background Understanding drivers of multidrug resistance (MDR) and methicillin resistance, which have increased among canine staphylococcal isolates, is essential for guiding antimicrobial use practices.
Jennifer Lord, Nick Millis, Rebekah Duckett Jones, Brian Johnson, Stephen A. Kania, Agricola Odoi   +5 more
doaj   +3 more sources

Patterns of antimicrobial, multidrug and methicillin resistance among Staphylococcus spp. isolated from canine specimens submitted to a diagnostic laboratory in Tennessee, USA: a descriptive study. [PDF]

BMC Vet Res, 2022
Background Multidrug- and methicillin-resistant staphylococci are both veterinary and public health concerns due to their zoonotic potential. Therefore, the objective of this study was to investigate patterns of antimicrobial, multidrug, and methicillin ...
Lord J, Millis N, Jones RD, Johnson B, Kania SA, Odoi A.   +5 more
europepmc   +2 more sources

Antimicrobial overuse and misuse in the community in Greece and link to antimicrobial resistance using methicillin-resistant S. aureus as an example

Journal of Infection and Public Health, 2019
Both antimicrobial consumption and antimicrobial resistance are very high in Greece, ranking among the highest of Europe. The link between antimicrobial consumption and resistance is well-known.
Stamatis Karakonstantis, Dimitra Kalemaki   +1 more
doaj   +2 more sources

Methicillin-resistant Staphylococcus aureus [PDF]

Nature Reviews Disease Primers, 2018
Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged, disseminated globally and become a leading cause of bacterial infections in both health-care and community settings. However, there is marked geographical variation in MRSA burden owing to several factors, including differences in local infection control practices and ...
Lee, Andie S.; de Lencastre, Herminia; Garau, Javier; Kluytmans, Jan; Malhotra-Kumar, Surbhi; Peschel, Andreas; Harbarth, Stephan   +7 more
semanticscholar   +8 more sources

Immunofluorescence Targeting PBP2a Protein: A New Potential Methicillin Resistance Screening Test [PDF]

Frontiers in Veterinary Science, 2021
The indiscriminate use of first-line drugs contributed to the spread of resistant bacteria, a major concern for both human and veterinary medicine. Methicillin resistance is acquired through the mecA gene, which encodes for the PBP2a protein and lends ...
Serenella Silvestri, Elisa Rampacci, Valentina Stefanetti, Michele Trotta, Caterina Fani, Lucia Levorato, Chiara Brachelente, Fabrizio Passamonti   +7 more
doaj   +2 more sources

Curcumin Reverse Methicillin Resistance in Staphylococcus aureus

Molecules, 2014
Curcumin, a natural polyphenolic flavonoid extracted from the rhizome of Curcuma longa L., was shown to possess superior potency to resensitize methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics. Previous studies have shown the synergistic
Su-Hyun Mun, Sung-Bae Kim, Ryong Kong, Jang-Gi Choi, Youn-Chul Kim, Dong-Won Shin, Ok-Hwa Kang, Dong-Yeul Kwon   +7 more
doaj   +2 more sources

Molecular Determinants of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus (MRSA): An Updated Review

Antibiotics, 2023
The development of antibiotic resistance in Staphylococcus aureus, particularly in methicillin-resistant S. aureus (MRSA), has become a significant health concern worldwide.
Harshad Lade, Jae-Seok Kim
semanticscholar   +1 more source