Results 171 to 180 of about 91,944 (251)

Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Here, we report isolation of acyl‐desferrioxamines from Actinoplanes teichomyceticus as a mixture of iron and aluminum complexes. The fraction containing these molecules exhibited antibacterial activity. We synthesized these molecules and found that they only exhibited antibacterial activity in the presence of aluminum.
Abiodun S. Oyedele, Somnath Jana, KyuOk Jeon, Navin Vazrala, Donald F. Stec, Kwangho Kim, Gary A. Sulikowski, Allison S. Walker   +7 more
wiley   +1 more source

Novel antibacterial peptide HfAMP against methicillin-resistant Staphylococcus aureus. [PDF]

BMC Microbiol
Lin F, Jin W, Yang L, Tian C, Zhang J, Jiao Z, Peng J, Guo G.   +7 more
europepmc   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

SHP-1 agonist SC-43 limits methicillin-resistant Staphylococcus aureus infection through inhibition of heme biosynthesis. [PDF]

EMBO Mol Med
Huang Y, Ye Y, Zhu X, Liang D, Cui R, Yuan X, Li X, Zou Q, Li H, Huang W.   +9 more
europepmc   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Unveiling the bactericidal effects of extracts and phytocompounds from Eichhornia crassipes (Mart.) Solms against methicillin-resistant Staphylococcus aureus (MRSA): An in vitro and in silico approach. [PDF]

PLoS One
Rahman MM, Simu SS, Shahir NF, Israt S, Rafi NI, Talukder MEK, Rahman MR, Jamal MAHM, Akhter S.   +8 more
europepmc   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher, Florian Heppner, Maximilian Seul, Simon Morgenschweis, Aia Ali Abdelrahman, Eva Fahr, Niklas Holstein, Anna Müller, Dirk Menche   +8 more
wiley   +1 more source

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite, Lucas H. S. Ocarino, Gabriel C. Veríssimo, Philipe O. Fernandes, Dara Fernanda Pereira, Fernanda Kelly M. e Oliveira, Alberto Marbán‐González, José L. Medina‐Franco, Mateus Sá M. Serafim, Thales Kronenberger, Vinícius G. Maltarollo   +10 more
wiley   +1 more source

Characterization and diversity of methicillin-resistant Staphylococcus aureus in two hospitals in Gabon. [PDF]

BMC Infect Dis
Gondi Nzamba BF, Otsaghe Ekore D, Dikoumba AC, Nzue Nguema J, Ntsaga Matamba EC, Dibakou SE, Okomo Y, Tsoumbou TA, Moussadji Kinga IC, Longo-Pendy NM, Medianikov O, Fenollar F, Pontier D, Ngoubangoye B.   +13 more
europepmc   +1 more source

Increased Risk of Environmental and Endemic Infectious Diseases in Sjögren's Disease: A Retrospective Analysis (2015–2023)

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Sjögren's disease (SjD) is a chronic autoimmune disease with a complex etiology, where pathogens may influence disease development or progression. Although SjD is not communicable, environmental and endemic pathogen exposures may influence its onset or progression.
Swetha K. Shankar, Taylor C. Boone, Eliza C. Diggins, Melodie L. Weller   +3 more
wiley   +1 more source