Results 11 to 20 of about 1,091,177 (248)

Pyrazole-Derived Antibacterial Compounds Effectively Treat Methicillin-Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase. [PDF]

Adv Sci (Weinh)
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Yang X, Cao X, Dai L, Yang F, Wang J, Ma Y, Bu T, Gong Z, Liu X, Bai C, Miao X, Shang X.   +11 more
europepmc   +2 more sources

Universal screening for meticillin-resistant Staphylococcus aureus : interim results from the NHS Scotland pathfinder project [PDF]

, 2009
Following recommendations from a Health Technology Assessment (HTA), a prospective cohort study of meticillin-resistant Staphylococcus aureus (MRSA) screening of all admissions (N = 29 690) to six acute hospitals in three regions in Scotland indicated ...
Masterton, R., Allardice, G., , Scottish Government Health Directorate (Funder), Reilly, Jacqui; id_orcid, Williams, C., Gould, I. M., Smith, A., Stewart, S., Gould, I.M., Christie, P., Scottish Government Health Directorate (Funder), Reilly, J.S.   +11 more
core   +4 more sources

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus [PDF]

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats: a case-control study. [PDF]

, 2010
Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats were investigated in an unmatched case-control study. A total of 197 animals from 150 veterinary practices across the United Kingdom was enrolled, including ...
Pfeiffer, Dirk Udo, Mick Rich, Soares Magalhães, RJ, Soares Magalhaes, Ricardo Jorge, Lindsay, Jodi, Lindsay, J, Lloyd, David Hugh, Larry Roberts, Loeffler, A, St George's, Lindsay, J A, Rich, M, Queensland, Australia, Pfeiffer, D U, Loeffler, Anette, Smith, H, Teringie SA, Australia, Smith, Heather, Soares-Magalhaes, R J, Lloyd, D H, Lloyd, DH, Roberts, Larry, Ricardo Jorge Soares Magalhães, Heather Smith, Rich, Mick, Anette Loeffler, Jodi Lindsay, David Hugh Lloyd, Dirk Udo Pfeiffer, Pfeiffer, DU, IDEXX Labs, Roberts, L   +31 more
core   +1 more source

Screening strategies in surveillance and control of methicillin-resistant Staphylococcus aureus (MRSA) [PDF]

, 2006
With reports of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) continuing to increase and therapeutic options decrease, infection control methods are of increasing importance.
Jenkins, D. R., Robotham, Julie, Medley, Graham   +2 more
core   +1 more source

Predominance of Methicillin Resistant Staphylococcus Aureus -ST88 and New ST1797 causing Wound Infection and Abscesses. [PDF]

, 2012
Although there has been a worldwide emergence and spread of methicillin-resistant Staphylococcus aureus (MRSA), little is known about the molecular epidemiology of MRSA in Tanzania.
Kamugisha, Erasmus, Lyamuya, Eligius F, Claus, Heike, Tappe, Dennis, Lyamuya, Eligius F., Moremi, Nyambura, Mshana, Stephen E., Kataraihya, Johannes B., Vogel, Ulrich, Mshana, Stephen E, Kataraihya, Johannes   +10 more
core   +1 more source

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus, Sequence Type 239 (TW) [PDF]

, 2010
The Sanger Institute is core funded by the Wellcome Trust. Funding for the sequencing of the TW20 genome was provided by Guy’s and St. Thomas’ Charity. J.D.E.
Edgeworth, Jonathan D., Quail, MA, Bentley, SD, Quail, Michael A., Parkhill, Julian, Corton, C, Parkhill, J, Lindsay, JA, Lindsay, Jodi A., Edgeworth, JD, Pathak, Smriti, Batra, R, Pathak, S, Bentley, Stephen D., Holden, MT, Holden, Matthew T. G., Cockfield, Joshua D., Batra, Rahul, Cockfield, JD, Corton, Craig   +19 more
core   +1 more source

Methicillin-resistant Staphylococcus aureus in Nepal

Journal of Nepal Medical Association, 2021
Staphylococcus aureus is both a frequent commensal and a leading cause of endocarditis, bacteremia, osteomyelitis and skin and soft tissue infections and device-related infections.
Lok Bahadur Shrestha, Gopiram Syangtan, Ajaya Basnet, Krishna Prasad Acharya, Arun Bahadur Chand, Khilasa Pokhrel   +5 more
doaj   +1 more source

Rapid PCR Detection of Staphylococcus aureus Clonal Complex 398 by Targeting the Restriction-Modification System Carrying sau1-hsdS1 [PDF]

, 2011
A PCR targeting sau1-hsdS1 was developed for rapid detection of Staphylococcus aureus clonal complex 398 (CC398). High sensitivity (100%) and specificity (100%) were shown by evaluating the test on a large strain collection (n = 1,307). We recommend this
Broens, Els M., Moodley, Arshnee, Guardabassi, L., Marc Stegger, Jodi A. Lindsay, Arshnee Moodley, Lindsay, J.A., Stegger, Marc, Broens, E.M., Els M. Broens, Skov, Robert, Moodley, A., Lindsay, Jodi A., Guardabassi, Luca, Skov, R., Robert Skov, Stegger, M., Luca Guardabassi   +17 more
core   +1 more source

The identification and characterization of a clinical isolate of a methicillin susceptible Staphylococcus aureus ST612 [PDF]

, 2012
Includes bibliographical references.A previous study of 100 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between January 2007 and December 2008 from five Cape Town hospitals, identified ST612-MRSA-IV as the predominant MRSA ...
Moleleki, Malefu
core   +1 more source