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Methimazole embryopathy: Delineation of the phenotype
American Journal of Medical Genetics Part A, 1999We report on a further case of congenital anomalies in a child exposed to methimazole during the first trimester of pregnancy (from first to seventh gestational week), and define a specific malformation pattern related to prenatal methimazole exposure and consisting of choanal and esophageal atresia, scalp defects, minor facial anomalies and ...
Maurizio Clementi
exaly +4 more sources
Desensitization to Methimazole
Endocrine Practice, 2021Thionamides (methimazole and propylthiouracil) have been associated with common side effects, such as rash and pruritus, and rare but serious adverse effects, such as agranulocytosis and hepatotoxicity. Methimazole is usually the preferred thionamide for the treatment of hyperthyroidism if the patient is not planning to conceive or not in the first ...
Alaleh, Mazhari +2 more
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Pharmacokinetics of methimazole in humans
Klinische Wochenschrift, 1985A newly developed method for extracting and measuring methimazole in biological fluids was used to study the pharmacokinetics of methimazole in two euthyroid and eight hyperthyroid subjects. The volume of distribution approximated total body water; the biological half-life was 2-3 h in euthyroid and about 6 h in hyperthyroid patients.
J H, Hengstmann, H, Hohn
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TOXICITY OF METHIMAZOLE (TAPAZOLE)
Journal of the American Medical Association, 1954Toxic manifestations of methimazole therapy have been documented by several investigators.1Skin rashes, agranulocytosis, arthritis, and toxic hepatitis have been reported. We wish to report the case of a patient treated with methimazole in whom a sudden marked neuropathy associated with foot drop developed.
G S, ACCETTA +2 more
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Methimazole-Induced Serum Sickness
Acta Clinica Belgica, 1983SummaryA female patient with multinodular goiter was treated with methimazole (MMI) for thyrotoxicosis. After 3 weeks, she developped sore throat, pruritus, arthralgias, facial oedema and fever. Biological data were suggesting a scrum sickness. To our knowledge, this is the first published case report of MMI-induced serum sickness. Acta Clin Belg.
Van Kuyk, M +3 more
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