Results 111 to 120 of about 166,521,371 (311)

BAYESIAN CURVE ESTIMATION BY MODEL AVERAGING [PDF]

open access: yes
A bayesian approach is used to estimate a nonparametric regression model. The main features of the procedure are, first, the functional form of the curve is approximated by a mixture of local polynomials by Bayesian Model Averaging (BMA); second, the ...
M. Dolores Redondas, Daniel Peña
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

An improved averaging combination method for image and object recognition

open access: yes, 2015
A key development in the design of visual object recognition systems is the combination of multiple features. In recent years, various popular optimization based feature combination methods have been proposed in the literatures.
Wang, Ronggang   +5 more
core   +1 more source

Determining the Performance of Procurement Methods against Selection Criteria using Outranking - Satisfying Methodology [PDF]

open access: yesJournal of Engineering, Project, and Production Management, 2013
The need to develop a decision support system to determine the most appropriate procurement route for a building project led to the development of various theoretical models. One of the foremost techniques was the multi-attribute utility approach (MAUA).
OJO Stephen Okunlola, IKPO Imeh Johnson
doaj  

Weighted Birkhoff Averages and the Parameterization Method

open access: yesSIAM Journal on Applied Dynamical Systems
38 pages, 15 ...
David Blessing, Jason D. Mireles-James
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Forecasting in Large Macroeconomic Panels using Bayesian Model Averaging [PDF]

open access: yes
This paper considers the problem of forecasting in large macroeconomic panels using Bayesian model averaging. Theoretical justifications for averaging across models, as opposed to selecting a single model, are given.
Gary Koop, Simon Potter
core  

Complexity of the method of averaging [PDF]

open access: yes, 2010
summary:The general method of averaging for the superapproximation of an arbitrary partial derivative of a smooth function in a vertex $a$ of a simplicial triangulation $\mathcal T$ of a bounded polytopic domain in $\Re^d$ for any $d\geq 2$ is described ...
Dalík, Josef
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy