Results 61 to 70 of about 178,120 (310)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Generalized Method of Moments [PDF]

, 2022
The topic of this bachelor thesis is the Generalized Method of Moments (GMM), its asymptotic properties, and its implementations. The first chapter briefly introduces the moment conditions and the Method of Moments (MM) which is then generalized to the ...
Volejníková, Viktorie
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An empirical investigation of option returns: overpricing and the role of higher systematic moments [PDF]

, 2004
The Capital Asset Pricing Model (CAPM) assumes either that all asset returns are normally distributed or that investors have mean-variance preferences. Given empirical observations of asset returns, which document evidence of skewness and kurtosis, both ...
O'Brien, F, Shackleton, M B, Fergal O'Brien, Mark B. Shackleton   +3 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Improving Consistent Moment Selection Procedures for Generalized Method of Moments Estimation [PDF]

This paper proposes consistent moment selection procedures for generalized method of moments estimation based on the J test of over-identifying restrictions (Hansen [1982]) and on the Eichenbaum, Hansen and Singleton [1988] test of the validity of a ...
Jean-Bernard Chatelain
core  

Hydrological regionalization of maximum stream flows using an approach based on L-moments [PDF]

, 2017
The proper design of hydraulic structures depends on estimates of maximum stream flows. The scarce stream flow monitoring in Brazil has led to the use of regionalization methods.
Samuel Beskow, Marcelle Martins Vargas (4702171), Leo Fernandes Ávila, Felício Cassalho, Maíra Martim de Moura, Leo Fernandes Ávila (4702165), Carlos Rogério de Mello, Samuel Beskow (4702162), Carlos Rogério de Mello (4626814), Maíra Martim de Moura (4702159), Marcelle Martins Vargas, Felício Cassalho (4702168)   +11 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Large Deviations of Generalized Method of Moments and Empirical  Likelihood Estimators [PDF]

This paper studies large deviation properties of the generalized method of moments and generalized empirical likelihood estimators for moment restriction models.
Taisuke Otsu
core