Results 101 to 110 of about 166,841,558 (307)

Solution of a quadratic nonlinear problem with multiple scales Lindstedt-Poincare method

, 2015
A recently developed perturbation algorithm namely the Multiple Scales Lindstedt-Poincare method (MSLP) is employed to solve an equation with quadratic nonlinearity.
SarI G., Pakdemirli M.
core   +1 more source

Statistical processing of qualitative (nominal) data in pharmacological research

Фармакокинетика и Фармакодинамика, 2019
The article deals with descriptive statistics of data measured using qualitative (categorical) scales and criteria for determining the statistical significance of differences between samples.
I. B. Tsorin
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

RESEARCH ON NONLINEAR VIBRATION FOR ELECTRICALLY ACTUATED SINGLE-WALLED CARBON NANOTUBE

Jixie qiangdu, 2016
This paper presents an investigation of the nonlinear problem of electrically actuated single-walled carbon nanotube. A clamped-clamped carbon nanotube connected to the fixed electrode plate,forming a capacitor under the external excitation voltage ...
YANG ZhiAn, LIU ZhiWei
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A multiple scales approach to maximal superintegrability

, 2018
In this paper we present a simple, algorithmic test to establish if a Hamiltonian system is maximally superintegrable or not. This test is based on a very simple corollary of a theorem due to Nekhoroshev and on a perturbative technique called the ...
Latini D., Gubbiotti G.
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Proxy measurements in multiple sclerosis: agreement on different patient-reported outcome scales

, 2011
Background: Patient-reported outcome (PRO) scales are often used in multiple sclerosis (MS) research. Full understanding of items can be influenced by disease worsening, mood disturbances and cognitive problems of the MS patient.
DL Knol, Knol, D.L., JM Sonder, Linden, F.A.H. van der, Polman, C.H., Bosma, L.V.A.E., Uitdehaag, B.M.J., BMJ Uitdehaag, FAH van der Linden, Sonder, J.M., LVAE Bosma, van der Linden, F.A.H., CH Polman   +12 more
core   +1 more source