Results 81 to 90 of about 427,874 (264)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Multiple Scale Methods For Optimization Of Discretized Continuous Functions

CoRR
26 pages, 7 figures, supplemental materials is 8 ...
Nicholas J. E. Richardson, Noah Marusenko, Michael P. Friedlander   +2 more
openaire   +2 more sources

Scaling analysis of multiple-try MCMC methods

Stochastic Processes and their Applications, 2012
The authors consider multiple-try Markov chain Monte Carlo (MCMC) algorithms. These are distinguished from standard MCMC algorithms in that the next state in the chain is chosen from a pool of proposals. In this study multiple proposals with a dependence structure are considered, extending work on independently distributed multiple proposals.
Bédard, Mylène, Douc, Randal, Moulines, Eric   +2 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Nonlinear vibration and stability of a moving printing web with variable density based on the method of multiple scales

Journal of Low Frequency Noise, Vibration and Active Control, 2019
An axially moving printing web with variable density in a printing process causes a geometric nonlinear vibration, and a nonlinear vibration system is established using the von Karman nonlinear plate theory and the D’Alembert principle.
Mingyue Shao, Jimei Wu, Yan Wang, Qiumin Wu, Zhen Tian   +4 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Advancing energy optimization in building systems through multi-scale sensitivity, adaptive modeling, and real-time management

Results in Engineering
This study provides a comprehensive assessment of building energy optimization through a systematic methodology utilizing Bayesian Adaptive Spline Surfaces (BASS) across multiple time scales.
Yaser Issam Hamodi Al-Janabi, Sameer Algburi, Omer Al-Dulaimi, Hassan Falah Fakhruldeen, Azamat Makhmudov, Doaa H. Khalaf, Talib Munshid Hanoon, Feryal Ibrahim Jabbar, Ali Khudhair Al-Jiboory, Qusay Hassan, Stella Kiconco   +10 more
doaj   +1 more source