Results 81 to 90 of about 166,841,558 (307)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Valuation of Credit Derivatives with Multiple Time Scales in the Intensity Model
, 2014 We propose approximate solutions for pricing zero-coupon defaultable bonds, credit default swap rates, and bond options based on the averaging principle of stochastic differential equations.
김범진, 박찬열
core
Introduction to the method of multiple scales
, 2013 Earlier versions of these lecture notes have been used at the Cork Summerschool on Theory and Mathematics Modelling of Ultrashort Pulse Propagation (2013), and as a part of a graduate course in the theory of nonlinear waves in the period 2014-2016. This version has an improved typography and numerous typoes has been corrected. It also has been extended
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Multiple time scales of bank-full discharge in the Yellow River
Shui kexue jinzhan, 2012 Under the influence of climate changes,the hydrologic system has the characteristics of multiple time scales.The bank-full discharge,as a function of inflow conditions,also has the characteristics of multiple time scales.This phenomenon was studied based
ZHANG Yan-yan, ZHONG De-yu, WU Bao-sheng
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Limitations of the Method of Multiple-Time-Scales
, 2002 In the Method of Multiple-Time-Scales (MMTS), the introduction of independent time scales and the elimination of secular terms in the fast time variable, T0 = t, lead to the well-known solvability conditions. Starting from first order, free terms (solutions of the unperturbed equations) emerge in every order in the expansion of the approximate solution.
Kahn, Peter B., Zarmi, Yair
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Application of the method of multiple scales to unravel energy exchange in nonlinear locally resonant metamaterials [PDF]
, 2018 In this paper, the effect of weak nonlinearities in 1D locally resonant metamaterials is investigated via the method of multiple scales. Commonly employed to the investigate the effect of weakly nonlinear interactions on the free wave propagation through
Silva, P. B. +4 more
core +1 more source