Results 31 to 40 of about 63,479 (265)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Criticism on the Field of Political Studies of the Islamic Revolution: The Convergence of the Four Methodological Domains [PDF]

پژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2017
As an event, the Islamic Revolution of Iran is seen as intertwined series of various factors and as a flow, it is considered as a nominal figure of innumerable events.
Zahed Ghafari Hashjin, Mohammad Aghaei
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nonlinear analysis of shells of revolution by the matrix displacement method. [PDF]

AIAA Journal, 1968
Matrix displacement method for nonlinear elastic analysis of shells of revolution under symmetrical and asymmetrical ...
Stricklin, J. A., Haisler, W. E., MacDougall, H. R., Stebbins, F. J.   +3 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The need for a (non-destructive) method revolution in entomology

Biological Conservation, 2023
There are worrying signs that arthropods are in decline both in density and diversity. This threatens global biodiversity as well as the ecosystem services provided by arthropods. Nonetheless, entomological research, even when studying arthropods with a conservation focus, frequently uses lethal methods. We analysed 1029 articles published in the major
Gábor L. Lövei, Marco Ferrante, Daniella Möller, Gabriella Möller, Éva Vincze   +4 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

STUDY OF A PROBLEM OF GRAPHIC ENGINEERING [PDF]

Fiabilitate şi Durabilitate, 2017
The paper proposes an approximate graphical method for determining the development of the revolution surface obtained by means of the deltoid. The approximate development of the revolution surfaces are based on general methods of development, provided ...
Liliana LUCA
doaj  

NONLINEAR DYNAMIC ANALYSIS OF SHELLS OF REVOLUTION BY MATRIX DISPLACEMENT METHOD [PDF]

11th Structures, Structural Dynamics, and Materials Conference, 1970
A formulation and computer program is developed for the geometrically nonlinear dynamic analysis of shells of revolution under symmetric and asymmetric loads. The nonlinear strain energy expression is evaluated using linear functions for all displacements.
Stricklin, J. A., Martinez, J. E., Tillerson, J. R., Hong, J. H., Haisler, W. E.   +4 more
openaire   +1 more source