Results 31 to 40 of about 61,270 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

REVOLUSI AKUNTAN 4.0

Jurnal Akuntansi Multiparadigma, 2021
Abstrak – Revolusi Akuntan 4.0 Tujuan Utama – Penelitian ini bertujuan untuk menganalisis eksistensi akuntan di masa revolusi industri 4.0 dan bagaimana cara mereka beradaptasi.
Bagas Brian Pratama, Nurafni Eltivia, Kurnia Ekasari   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Criticism on the Field of Political Studies of the Islamic Revolution: The Convergence of the Four Methodological Domains [PDF]

پژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2017
As an event, the Islamic Revolution of Iran is seen as intertwined series of various factors and as a flow, it is considered as a nominal figure of innumerable events.
Zahed Ghafari Hashjin, Mohammad Aghaei
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The need for a (non-destructive) method revolution in entomology

Biological Conservation, 2023
There are worrying signs that arthropods are in decline both in density and diversity. This threatens global biodiversity as well as the ecosystem services provided by arthropods. Nonetheless, entomological research, even when studying arthropods with a conservation focus, frequently uses lethal methods. We analysed 1029 articles published in the major
Gábor L. Lövei, Marco Ferrante, Daniella Möller, Gabriella Möller, Éva Vincze   +4 more
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

STUDY OF A PROBLEM OF GRAPHIC ENGINEERING [PDF]

Fiabilitate şi Durabilitate, 2017
The paper proposes an approximate graphical method for determining the development of the revolution surface obtained by means of the deltoid. The approximate development of the revolution surfaces are based on general methods of development, provided ...
Liliana LUCA
doaj  

NONLINEAR DYNAMIC ANALYSIS OF SHELLS OF REVOLUTION BY MATRIX DISPLACEMENT METHOD [PDF]

11th Structures, Structural Dynamics, and Materials Conference, 1970
A formulation and computer program is developed for the geometrically nonlinear dynamic analysis of shells of revolution under symmetric and asymmetric loads. The nonlinear strain energy expression is evaluated using linear functions for all displacements.
Stricklin, J. A., Martinez, J. E., Tillerson, J. R., Hong, J. H., Haisler, W. E.   +4 more
openaire   +1 more source