Results 141 to 150 of about 1,892,546 (315)
Validation procedures in radiological diagnostic models. Neural network and logistic regression [PDF]
The objective of this paper is to compare the performance of two predictive radiological models, logistic regression (LR) and neural network (NN), with five different resampling methods.
Pedro Delicado +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Statistical Analysis of Spatial Dynamic Pattern in Spatial Data Analysis [PDF]
, 2013 In this thesis, inspired by the Boston House Price data, we propose a semiparametric spatial dynamic model, that extends the ordinary spatial autoregressive models to accommodate the effects of some covariates associated with the House price.
Yan, Hongjia
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Method validation for mycotoxin analysis
Mycotoxins, 2006 分析法の妥当性確認は、分析の精度を保証するための第一歩となる基本事項である。分析法の妥当性確認方法としては、国際ハーモナイズドプロトコールに基づいたフルコラボスタディー（HCV)があるが、これのみを分析法の妥当性確認法と考える必要はなく、分析法にその目的適合性があるように、その分析法の試料目的に合わせた妥当性確認法を選択してMethod Validationを行う必要がある。Method Validationの世界ではAOACインターナショナルが大きな役割を果たしてきたが、近年はその妥当性確認に関して多様な新しい要求が出てきている。しかし妥当性確認された分析法を適切な適用性確認を経て使用することは分析の品質保証の第一歩であり重要なことである。
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
ChemosensorsAlcohol consumption is a major social and forensic issue. It is often the cause of road accidents, industrial accidents, suicides and other crimes. On account of this, it is of fundamental importance in forensic toxicology to correctly quantify blood ...
Alice Cerioni +7 more
doaj +1 more source
, 1986 Aim of this investigation was to give a contribution to the validation of the HOEDE simulation model. The HOEDE model is an ecosystem simulation model, simulating the carbonflux through the Ems-Dollard estuary system. There seems to be a variety of statistical tests to validate a simulation model but most of them have a restriction: autocorrelation ...
openaire
Method validation: A complex concept
Pharmaceutical Methods, 2011 The reader will find that many of the articles that are published in the current issue refer to method validation and in particular to the International Conference on Harmonization (ICH) guidelines as the basis for their approach. The ICH was launched in 1990, with the objective of harmonizing technical and regulatory approaches in the Pharma-Chem ...
openaire +3 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
YREE determination in seawater. Standardization and validation of a new method based on preconcentration techniques [PDF]
, 2010 The most interesting attraction of using rare-earth elements and yttrium (YREE) to address geochemical and marine chemical problems consists of their chemical coherence as group of trace elements.
CENSI, Paolo +3 more
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