Results 231 to 240 of about 3,970,126 (291)

Personalization of pharmacotherapy with sirolimus based on volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients-from LC-MS/MS method validation to clinical application. [PDF]

Pharmacol Rep
Kocur A, Czajkowska A, Rębis K, Rubik J, Moczulski M, Kot B, Sierakowski M, Pawiński T.   +7 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A high-performance liquid chromatography method validation and a Box-Behnken experimental design for the extraction optimization of quercitrin from Nectandra reticulata. [PDF]

RSC Adv
Pulido Teuta J, Narváez-Cuenca CE, Ávila Murillo M.   +2 more
europepmc   +1 more source

Advancing Bioanalytical Method Validation: A Comprehensive ICH M10 Approach for Validating LC-MS/MS to Quantify Fluoxetine in Human Plasma and Its Application in Pharmacokinetic Studies. [PDF]

Molecules
El Orche A, Cheikh A, El Khabbaz C, Bouchafra H, Faouzi MEA, Cherrah Y, Ansari SA, Alkahtani HM, Ansari SA, Bouatia M.   +9 more
europepmc   +1 more source

Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry. [PDF]

Front Mol Biosci
Seiffert S, Weber S, Sack U, Keller T.
europepmc   +1 more source

HSPiP, Computational Modeling, and QbD-Assisted Optimized Method Validation of 5-Fluorouracil for Transdermal Products. [PDF]

ACS Omega
Hussain A, Ramzan M, Altamimi MA, Khuroo T, Mohd Siddique MU, Alnemer OA.   +5 more
europepmc   +1 more source

Use of Uncertainty Calculation Software as a Didactic Tool to Improve the Knowledge of Chemistry Students in Analytical Method Validation. [PDF]

J Chem Educ
Cerrato-Alvarez M, Frutos-Puerto S, Pinilla-Gil E.   +2 more
europepmc   +1 more source

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Validation of Bioanalytical Methods

Pharmaceutical Research, 1991
Validation of bioanalytical methods used to generate data for pharmacokinetic and bioavailability studies is approached by a variety of techniques and is subject to many different methods of interpretation. This Review puts the various techniques into perspective and discusses pitfalls which may occur in interpretation of validation data.
H T, Karnes, G, Shiu, V P, Shah
openaire   +2 more sources

Validation of new methods

Forensic Science International, 2007
Reliable analytical data are a prerequisite for correct interpretation of toxicological findings in the evaluation of scientific studies, as well as in daily routine work. Unreliable analytical data might not only be contested in court, but could also lead to unjustified legal consequences for the defendant or to wrong treatment of the patient ...
Frank T, Peters, Olaf H, Drummer, Frank, Musshoff   +2 more
openaire   +2 more sources

Cross-Validation Methods

Journal of Mathematical Psychology, 2000
This paper gives a review of cross-validation methods. The original applications in multiple linear regression are considered first. It is shown how predictive accuracy depends on sample size and the number of predictor variables. Both two-sample and single-sample cross-validation indices are investigated. The application of cross-validation methods to
openaire   +3 more sources