Results 81 to 90 of about 8,745,280 (351)
ConfinsThis article presents a methodological guide for analyzing COVID-19 at the intra-urban scale in non-metropolitan areas of south-central Brazil. To this end, it briefly discusses the COVID-19 pandemic and pertinent questions for making COVID-19 maps in ...
João Pedro Pereira Caetano de Lima +1 more
doaj +1 more source
ANALYSIS OF ROMANIA’S ENERGY MANAGEMENT FROM 2000 UNTIL TODAY [PDF]
Annals of the University of Oradea: Economic Science, 2017 The aim of energy management is to provide good quality and proper quantity energy in an economic and continuous way for the energy consumers in different parts of the country with minimal energy costs.
Csipkés Margit +2 more
doaj
Too Good to be False: Nonsignificant Results Revisited
Collabra: Psychology, 2017 Due to its probabilistic nature, Null Hypothesis Significance Testing (NHST) is subject to decision errors. The concern for false positives has overshadowed the concern for false negatives in the recent debates in psychology.
Chris H. J. Hartgerink +2 more
doaj +1 more source
Plant based diet and cardio-metabolic disease
Journal of Education, Health and Sport, 2020 Introduction: Modern lifestyle, especially diet have a great impact on health. The number of people suffering from conditions related to lifestyle is growing rapidly.
Justyna Dąbrowska +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Q methodology: an overview [PDF]
, 2011 If you have ever wanted to know the ‘points of view’that are held around a particular topic then oneof the methods available for you to uncover theseviews is Q methodology.
Coogan, Joy, Herrington, Neil
core +1 more source