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Methodological studies of PIXE on biological and environmental science [PDF]
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1996 The Van de Graaff Facility at IHEP is mainly used for PIXE research work especially on biologicial and environmental science. The sensitivities and the number of analyzed trace elements were improved greatly using special absorbers for bone and whole blood samples. Quite good results were obtained for different biomedical research work. Several methods
Sha Yin +9 more
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Simplified HPLC methodology for quantifying biological pterins by selective oxidation
Journal of Chromatography B, 2017 Tetrahydrobiopterin (BH4) has become a potential therapeutic tool to treat cardiovascular diseases, since it is an essential cofactor of nitric oxide synthase. In order to quantify the amount of BH4 and its related biopterins, a procedure that involves differential oxidation is currently used, which measures biopterin (the product of the oxidation of ...
Valdes, Cristian +3 more
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
iScience, 2021 Summary: Spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. The cultures are maintained under different conditions, with possible confounding results. We performed an in-depth analysis of the
Niklas Handin +10 more
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Top-down reconfiguration of SMA cortical connectivity during action preparation
iScience, 2023 Summary: The Bereitschaftspotential (BP), a scalp potential recorded in humans during action preparation, is characterized by a slow amplitude increase over fronto-central regions as action execution approaches.
Valentina Bianco +4 more
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Influence of data sampling methods on the representation of neural spiking activity in vivo
iScience, 2022 Summary: In vivo single-unit recordings distinguish the basal spiking properties of neurons in different experimental settings and disease states. Here, we examined over 300 spike trains recorded from Purkinje cells and cerebellar nuclei neurons to test ...
Meike E. van der Heijden +2 more
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iScience, 2022 Summary: While microbial communities inhabit a wide variety of complex natural environments, in vitro culturing enables highly controlled conditions and high-throughput interrogation for generating mechanistic insights.
Arianna I. Celis +6 more
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Visualizing lymphocytic choriomeningitis virus infection in cells and living mice
iScience, 2022 Summary: Mammarenavirus are a large family of enveloped negative-strand RNA viruses that include several agents responsible for severe hemorrhagic fevers.
Yuxi Wen +11 more
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iScience, 2021 Summary: Since the beginning of the COVID-19 pandemics, variants have emerged. Some of them display increased transmissibility and/or resistance to immune response.
Eva Lopez +9 more
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iScience, 2023 Summary: A simple and robust cell culture system is essential for generating authentic SARS-CoV-2 stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and preparation of inactivated vaccines.
Da-Yuan Chen +18 more
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A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells
iScience, 2022 Summary: The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust in vitro derivation methods.
Zaniar Ghazizadeh +21 more
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