Results 41 to 50 of about 119,724,969 (305)

HIV-1 env gene mutations outside the targeting probe affects IPDA efficiency

iScience
Summary: The intact proviral DNA assay (IPDA) based on droplet digital PCR was developed to identify intact proviral DNA and quantify HIV-1 latency reservoirs in patients infected with HIV-1.
Zehua Zhou, Xinyu Zhang, Meiyu Wang, Fei Jiang, Jincheng Tong, Jianhui Nie, Chenyan Zhao, Haifa Zheng, Zhen Zhang, Penghui Shi, Weiguang Fan, Youchun Wang, Weijin Huang   +12 more
doaj   +1 more source

METHODOLOGY OF USING MODERN APPROACHES AND INNOVATIONS IN TEACHING BIOLOGICAL SCIENCE IN UNIVERSAL EDUCATION SCHOOLS

, 2023
This article explores the methodology and implementation of contemporary approaches and innovations in teaching biological science within the context of universal education schools. With the rapid advancements in science and technology, educators are continually seeking effective strategies to engage students and enhance their learning experiences in ...
openaire   +2 more sources

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

A rationally designed optochemogenetic switch for activating canonical Wnt signaling

iScience, 2023
Summary: Accurate spatiotemporal control of multicellular self-organization by various signaling pathways is essential for developmental stages. In particular, evolutionarily conserved Wnt signaling serves as a major morphogenetic switch to determine the
Seunghwan Lee, Mingguang Cui, Donghun Lee, Kihoon Han, Woong Sun, Dongmin Lee   +5 more
doaj   +1 more source

Methodology for Writing Review Articles in Biological Sciences: A Systematic and Scholarly Guide

Archives of Current Research International
Review articles (RA) play a central role in the advancement of biological sciences by synthesizing dispersed knowledge, identifying conceptual trends, evaluating methodological progress and proposing future research directions. Unlike primary research articles, reviews demand a high level of critical judgment, scholarly balance and methodological rigor
Sahu, Jaydeep Kumar, Sureshrao, Ghodke Anita, Majhi, Saraswati, Dimri, Rakhee, Sharma, Bhagwati Prashad, Tailor, Vikas, Kumar, Sanjeet, Patra, Arjun   +7 more
openaire   +2 more sources

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation

iScience, 2022
Summary: Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein VI (
Delia I. Fernández, Isabella Provenzale, Hilaire Y.F. Cheung, Jan van Groningen, Bibian M.E. Tullemans, Alicia Veninga, Joanne L. Dunster, Saman Honarnejad, Helma van den Hurk, Marijke J.E. Kuijpers, Johan W.M. Heemskerk   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Beyond the null: Recognizing and reporting true negative findings

iScience
Summary: Science is based on ideas that might be true or false in describing reality. In order to discern between these two, scientists conduct studies that can reveal evidence for an idea, i.e., positive findings, or not, i.e., negative or null findings.
Manon K. Schweinfurth, Joachim G. Frommen   +1 more
doaj   +1 more source

Visualization and analysis of whole depot adipose tissue neural innervation

iScience, 2021
Summary: Little is known about the diversity and function of adipose tissue nerves, due in part to the inability to effectively visualize the tissue’s diverse nerve subtypes and the patterns of innervation across an intact depot.
Jake W. Willows, Magdalena Blaszkiewicz, Amy Lamore, Samuel Borer, Amanda L. Dubois, Emma Garner, William P. Breeding, Karissa B. Tilbury, Andre Khalil, Kristy L. Townsend   +9 more
doaj   +1 more source