Results 41 to 50 of about 1,338,720 (273)

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

iScience
Summary: Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue tropism. Because the gene size of RNA viruses is typically small, NanoLuc is the primary choice for accommodation within viral genome.
Tomokazu Tamura, Hayato Ito, Shiho Torii, Lei Wang, Rigel Suzuki, Shuhei Tsujino, Akifumi Kamiyama, Yoshitaka Oda, Masumi Tsuda, Yuhei Morioka, Saori Suzuki, Kotaro Shirakawa, Kei Sato, Kumiko Yoshimatsu, Yoshiharu Matsuura, Satoshi Iwano, Shinya Tanaka, Takasuke Fukuhara   +17 more
doaj   +1 more source

Uniform transgene activation in Tet-On systems depends on sustained rtTA expression

iScience, 2023
Summary: Application of the tetracycline-inducible gene expression system (Tet-On) in human induced pluripotent stem cells (hiPSCs) has become a fundamental transgenic tool owing to its regulatable gene expression.
Jun Otomo, Knut Woltjen, Hidetoshi Sakurai   +2 more
doaj   +1 more source

Diffusive optical tomography in the Bayesian framework [PDF]

, 2019
Many naturally-occuring models in the sciences are well-approximated by simplified models, using multiscale techniques. In such settings it is natural to ask about the relationship between inverse problems defined by the original problem and by the ...
Li, Qin, Newton, Kit, Stuart, Andrew
core   +1 more source

Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age

iScience, 2023
Summary: Nicotinamide adenine dinucleotide (NAD) can be used as an initiating nucleotide in RNA transcription to produce NAD-capped RNA (NAD-RNA).
Dean Li, Shuwen Ge, Yandong Liu, Miaomiao Pan, Xueting Wang, Guojing Han, Sili Zou, Rui Liu, Kongyan Niu, Chao Zhao, Nan Liu, Lefeng Qu   +11 more
doaj   +1 more source

Lost in translation: data integration tools meet the Semantic Web (experiences from the Ondex project)

, 2011
More information is now being published in machine processable form on the web and, as de-facto distributed knowledge bases are materializing, partly encouraged by the vision of the Semantic Web, the focus is shifting from the publication of this ...
A. Splendiani, C. Goble, E. Neumann, G.A. Pavlopoulos, K. Koheler, P. Heim, P. Karp, P. Shannon, S.B. Davidson   +8 more
core   +1 more source

Physics for non-physicists - Two bio-degrees reforms in Spanish universities: Health Biology and Biology [PDF]

, 2019
We present a review of two different innovative experiences of Physics education for Bio-Sciences in two Spanish Universities - the Health Biology degree of the Universidad de Alcalá de Henares (UAH) and the Biology degree of the Universidad Autónoma de ...
Cussó, F., Del Romero, A., Herrera-Melle, L., Lifante, G., Sancho, M.   +4 more
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Detection and annotation of transposable element insertions and deletions on the human genome using nanopore sequencing

iScience, 2023
Summary: Repetitive sequences represent about 45% of the human genome. Some are transposable elements (TEs) with the ability to change their position in the genome, creating genetic variability both as insertions or deletions, with potential pathogenic ...
Javier Cuenca-Guardiola, Belén de la Morena-Barrio, Esther Navarro-Manzano, Jonathan Stevens, Willem H. Ouwehand, Nicholas S. Gleadall, Javier Corral, Jesualdo Tomás Fernández-Breis   +7 more
doaj   +1 more source

New Silver Nanosensor for Nickel Traces. Part II: Urinary Nickel Determination Associated to Smoking Addiction [PDF]

, 2012
A new fluorescence silver nanosensor assisted by surfactant has been recently synthesized and applied to ultra trace nickel determination. The methodology was validated by the standard addition method and satisfactorily applied to nickel determination in
Fernandez, Liliana Patricia, Luconi, Marta Olga, Talio, María Carolina   +2 more
core  

Rapid Assessment of Intertidal Wetland Sediments [PDF]

, 2012
Urbanization of coastal areas poses a severe threat to ecologically valuable intertidal wetlands. This paper presents a pragmatic approach called Rapid Assessment for Intertidal Wetland Sediments (RAITWS) for evaluating the sediment quality of intertidal
Borthwick, Alistair G. L., Fang, Yuan, Ni, Jinren, Sun, Jinshui   +3 more
core   +1 more source