Results 61 to 70 of about 573,237 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A rationally designed optochemogenetic switch for activating canonical Wnt signaling

iScience, 2023
Summary: Accurate spatiotemporal control of multicellular self-organization by various signaling pathways is essential for developmental stages. In particular, evolutionarily conserved Wnt signaling serves as a major morphogenetic switch to determine the
Seunghwan Lee, Mingguang Cui, Donghun Lee, Kihoon Han, Woong Sun, Dongmin Lee   +5 more
doaj   +1 more source

The "Gut Game": an active methodology to teach digestive physiology.

Advances in Physiology Education, 2020
Rafael Paschoal de Campos, Victória Pereira Viero, Natascha Monteiro Medeiros, Fernanda Klein Marcondes, X Luís Henrique Montrezor, Marilene Porawski, and Lucila Ludmila Paula Gutierrez Biomedicine Undergraduate Program, Federal University of Health ...
R. D. de Campos, Victória Pereira Viero, Natascha Monteiro Medeiros, F. K. Marcondes, L. Montrezor, M. Porawski, Lucila Ludmila Paula Gutierrez   +6 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation

iScience, 2022
Summary: Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein VI (
Delia I. Fernández, Isabella Provenzale, Hilaire Y.F. Cheung, Jan van Groningen, Bibian M.E. Tullemans, Alicia Veninga, Joanne L. Dunster, Saman Honarnejad, Helma van den Hurk, Marijke J.E. Kuijpers, Johan W.M. Heemskerk   +10 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Beyond the null: Recognizing and reporting true negative findings

iScience
Summary: Science is based on ideas that might be true or false in describing reality. In order to discern between these two, scientists conduct studies that can reveal evidence for an idea, i.e., positive findings, or not, i.e., negative or null findings.
Manon K. Schweinfurth, Joachim G. Frommen   +1 more
doaj   +1 more source

Visualization and analysis of whole depot adipose tissue neural innervation

iScience, 2021
Summary: Little is known about the diversity and function of adipose tissue nerves, due in part to the inability to effectively visualize the tissue’s diverse nerve subtypes and the patterns of innervation across an intact depot.
Jake W. Willows, Magdalena Blaszkiewicz, Amy Lamore, Samuel Borer, Amanda L. Dubois, Emma Garner, William P. Breeding, Karissa B. Tilbury, Andre Khalil, Kristy L. Townsend   +9 more
doaj   +1 more source

TEACHING METHODOLOGY OF BIOLOGICAL SCIENCE IN SCHOOLS

Teaching methodology in biological science plays a crucial role in shaping students' understanding and interest in the subject. This article explores various innovative teaching methods and strategies that can be employed in schools to enhance the learning experience and promote a deeper understanding of biological concepts. It discusses the importance
Abatova Feruza Reymbaevn, Xojalepesova Gulistan Muratbekovna, Tulepova Gulbanu Moynaqbaevna   +2 more
openaire   +1 more source

Goltz against cerebral localization: Methodology and experimental practices.

Studies in history and philosophy of biological and biomedical sciences, 2020
In the late 19th century, physiologists such as David Ferrier, Eduard Hitzig, and Hermann Munk argued that cerebral brain functions are localized in discrete structures. By the early 20th century, this became the dominant position.
J. P. Gamboa
semanticscholar   +1 more source