Results 121 to 130 of about 3,716,507 (339)

An evaluation of the articulation of public policies on inclusive education in training of teachers at the State University of Maringá [PDF]

The article discusses the initial training of teachers from the perspective of inclusive education The current proposal for Inclusive Education is based on the Salamanca Declaration (Brazil, 1994a) - A document approved on 10 June 1994, at the World ...
Barros, Marcelo Alves, Costa, Luciano Gonsalves, Fonseca, Gisele Montagnoli da, Maciel, Aline Terumi Bomura   +3 more
core  

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source

HIV-1 env gene mutations outside the targeting probe affects IPDA efficiency

iScience
Summary: The intact proviral DNA assay (IPDA) based on droplet digital PCR was developed to identify intact proviral DNA and quantify HIV-1 latency reservoirs in patients infected with HIV-1.
Zehua Zhou, Xinyu Zhang, Meiyu Wang, Fei Jiang, Jincheng Tong, Jianhui Nie, Chenyan Zhao, Haifa Zheng, Zhen Zhang, Penghui Shi, Weiguang Fan, Youchun Wang, Weijin Huang   +12 more
doaj  

Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation

iScience, 2022
Summary: Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein VI (
Delia I. Fernández, Isabella Provenzale, Hilaire Y.F. Cheung, Jan van Groningen, Bibian M.E. Tullemans, Alicia Veninga, Joanne L. Dunster, Saman Honarnejad, Helma van den Hurk, Marijke J.E. Kuijpers, Johan W.M. Heemskerk   +10 more
doaj  

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

A rationally designed optochemogenetic switch for activating canonical Wnt signaling

iScience, 2023
Summary: Accurate spatiotemporal control of multicellular self-organization by various signaling pathways is essential for developmental stages. In particular, evolutionarily conserved Wnt signaling serves as a major morphogenetic switch to determine the
Seunghwan Lee, Mingguang Cui, Donghun Lee, Kihoon Han, Woong Sun, Dongmin Lee   +5 more
doaj  

A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences

Brazilian Journal of Medical and Biological Research, 2005
cDNA microarray is an innovative technology that facilitates the analysis of the expression of thousands of genes simultaneously. The utilization of this methodology, which is rapidly evolving, requires a combination of expertise from the biological ...
V. de Mello-Coelho, K.L. Hess
doaj   +1 more source

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1170-1187, April 2025.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies, Raja Ganesen, John Toubia, Sung‐Ha Hong, Sushil Kumar KC, Martin K. Oehler, Carmela Ricciardelli, Endre J. Szili, Nirmal Robinson, Melissa R. Pitman   +9 more
wiley   +1 more source

Activity-based probes trap early active intermediates during metacaspase activation

iScience, 2022
Summary: Metacaspases are essential cysteine proteases present in plants, fungi, and protists that are regulated by calcium binding and proteolytic maturation through mechanisms not yet understood.
Vida Štrancar, Katarina P. van Midden, Daniel Krahn, Kyoko Morimoto, Marko Novinec, Christiane Funk, Simon Stael, Christopher J. Schofield, Marina Klemenčič, Renier A.L. van der Hoorn   +9 more
doaj  

"A network of mutualities of being": socio-material archaeological networks and biological ties at Çatalhöyük [PDF]

arXiv
Recent advances in archaeogenomics have granted access to previously unavailable biological information with the potential to further our understanding of past social dynamics at a range of scales. However, to properly integrate these data within archaeological narratives, new methodological and theoretical tools are required.
arxiv