Results 111 to 120 of about 119,724,969 (305)

Integrity assay for messenger RNA in mouse and human brain samples and synaptosomal preparations

iScience
Summary: Traditionally, RNA integrity evaluation is based on ribosomal RNAs (rRNAs). Nevertheless, gene expression studies are usually focused on protein-coding messenger RNAs (mRNAs).
Daina Bujanauskiene, Kajus Merkevicius, Ugne Kuliesiute, Jaroslav Denkovskij, Simonas Kutanovas, Gediminas Luksys, Saulius Rocka, Eiva Bernotiene, Urte Neniskyte   +8 more
doaj   +1 more source

Journal of Methodology of Social Sciences and Humanities; No. 116

The main objective of Methodology of Humanities and Social Sciences (MSSH) is to provide an intellectual platform for national and international researchers to discuss their most recent findings related to philosophical foundations and methodology of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

College of Biological Sciences Commencement Program, 2020

, 2020
University of Minnesota; College of Biological Sciences. (2020). College of Biological Sciences Commencement Program, 2020.
College of Biological Sciences, University of Minnesota   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Initial training of biological sciences teachers: living the interactive methodology as teaching tools

, 2010
The present paper, developed with a group of second period of Biology Degree, had as main objective analyze our experience in the utilization of interactive methodology as didactic tool. Questionnaires and interviews were used with students in the process of collecting data; besides participant observation.
Araújo, Monica Lopes Folena, de Oliveira, Maria Marly, de França, Tereza Luiza   +2 more
openaire   +1 more source

Investigation regarding the occurrence and methodology adopted in teaching-learning about cells in the experiences of undergraduates in Biological Sciences during their supervised internships

, 2020
The present work had as objective, to investigate the occurrence of the teaching-learning on cells experienced by graduates in Biological Sciences and the methodologies adopted for this process during their supervised internships in schools. The research carried out was exploratory, of a qualitative and quantitative nature and the data were collected ...
Ribeiro, Felipe dos Santos, Silva, Flavia Venancio   +1 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

CRISPR/dCas9-targeted H3K27me3 demethylation at the CUC3 boundary gene triggers ectopic transcription and impacts plant development

iScience
Summary: Chromatin modifications are deemed to correlate with gene expression patterns, yet their direct causal effect on transcription and cell fate remains unestablished. The H3K27me3 modification, highly conserved in eukaryotes, is strongly associated
Kateryna Fal, Salim El Khoury, Marie Le Masson, Alexandre Berr, Cristel C. Carles   +4 more
doaj   +1 more source

Journal of Methodology of Social Sciences and Humanities (MSSH); 113.no

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source