Results 101 to 110 of about 123,390,688 (306)

Journal of Methodology of Social Sciences and Humanities ; No.81

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, Journal of, Methodology of Social Sciences and Humanities, J (via Mendeley Data)   +1 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No.88

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data), Methodology of Social Sciences and Humanities, Journal of   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No. 111

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data), Methodology of Social Sciences and Humanities, Journal of   +1 more
core   +1 more source

Reporting quality of systematic reviews published from 2011 to 2024 in the Journal of Korean Biological Nursing Science based on the PRISMA 2020 checklist: a methodological review

Journal of Korean Biological Nursing Science
Purpose: This study evaluated the reporting quality of systematic reviews (SRs) published in the Journal of Korean Biological Nursing Science (JKBNS) from 2011 to 2024 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline and examined conceptual alignment with A Measurement Tool to Assess Systematic ...
Mi-Kyoung Cho, Mi Young Kim
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No.118

Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data), Methodology of Social Sciences and Humanities, Journal of   +1 more
core   +1 more source

Agarose hydrogel-mediated electroporation method for retinal tissue cultured at the air-liquid interface

iScience
Summary: It is advantageous to culture the ex vivo retina and other tissues at the air-liquid interface to allow for more efficient gas exchange. However, gene delivery to these cultures can be challenging.
Megan L. Stone, Hannah H. Lee, Edward M. Levine   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source