Results 121 to 130 of about 568,188 (255)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Predictive modeling in biology and medicine: Digital twins and multi-scale modeling. [PDF]

PLoS Comput Biol
Alber M, Smith A, Laubenbacher R, Merks RMH.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Differential effects of fresh and black garlic extracts on oxidative stress regulation and anti-inflammatory response properties in human HepG2 cells: An <i>in vitro</i> study. [PDF]

Front Pharmacol
Almughamisi M, Amer F, Alqahtani NK, Felemban AH, Jawharji MT, Hafiz HA, Wazzan H, Altuwairki D, Alharbi HF, Algheshairy RM, Altalhi R, Qahl SH, Alzahrani MS, Abu Ali OA, Sami R, Izmirly AM.   +15 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A reproducible infection protocol for entomopathogenic nematodes in the natural host <i>Plodia interpunctella</i> larvae. [PDF]

MethodsX
Mallick S, Chakkalakkal GJ, Kirby T, Isaac J, Lažetić V, Eleftherianos I.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

CAG-targeting artificial miRNA with reduced off-target risk for efficient lowering of pathogenic polyglutamine proteins. [PDF]

NAR Mol Med
Pewinska-Kolodziejczak M, Kotowska-Zimmer A, Przybyl L, Wronka D, Karlik A, Smuszkiewicz M, Balcerek J, Suszynska-Zajczyk J, Piaszyk-Borychowska A, Urbanek-Trzeciak M, Sablok G, Kozlowska E, Podkowinski J, Fiszer A, Kozlowski P, Handschuh L, Olejniczak M.   +16 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Aptamer-based analyses of plasma proteome in individuals with post-COVID condition who underwent tailored physical activity. [PDF]

Front Sports Act Living
Chowdhury MMH, Fontaine MN, Lord SE, Lucier JF, Allard-Chamard H, Ilangumaran S, Piché A, Dionne IJ, Ramanathan S.   +8 more
europepmc   +1 more source