Results 171 to 180 of about 119,724,969 (305)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The association of sleep health with epigenetic aging in early adolescence: exploratory insights from the Health Outcomes and Measures of the Environment study. [PDF]

Sleep Adv
Maskey S, Arzu J, Chen A, Kelsey KT, Langevin SM, Cecil KM, Yolton K, Braun JM, Sears CG.   +8 more
europepmc   +1 more source

Journal of Methodology of Social Sciences and Humanities ; No.68

The main objective of Methodology of Humanities and Social Sciences (MSSH) is to provide an intellectual platform for national and international researchers to discuss their most recent findings related to philosophical foundations and methodology of ...
Methodology of Social Sciences and Humanities, Journal of, Methodology of Social Sciences and Humanities, J (via Mendeley Data)   +1 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

From regulatory approval to clinical practice: real-world eligibility for anti-amyloid monoclonal antibodies in an Italian dementia-care network. [PDF]

J Prev Alzheimers Dis
Zamboni G, Tondelli M, Vinceti G, Gallingani C, Bercini Z, Barbieri A, Carbone C, Iacovino N, Cossutti S, Ballotta D, Salemme S, Chiari A.   +11 more
europepmc   +1 more source

Journal of Methodology of Social Sciences and Humanities ; No.71

The main objective of Methodology of Humanities and Social Sciences (MSSH) is to provide an intellectual platform for national and international researchers to discuss their most recent findings related to philosophical foundations and methodology of ...
Methodology of Social Sciences and Humanities, Journal of, Methodology of Social Sciences and Humanities, J (via Mendeley Data)   +1 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Blood-based biomarkers of Alzheimer's disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms. [PDF]

NPJ Dement
Akinyemi T, Pola I, Tan K, Olalusi O, Yaria J, Ogunde G, Traichel W, Rahmouni N, Oguntiloye O, Fagbemi A, Cadmus E, Popoola F, Therriault J, Ogunronbi M, Olujobi D, Famuyiwa O, Akinyemi J, Pascoal T, Owolabi M, Rosa-Neto P, Udeh-Momoh CT, Ladokun O, Romero-Ortuno R, Ogunniyi A, Lawlor B, Kalaria R, Zetterberg H, Benedet AL, Akinyemi R.   +28 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source