Results 181 to 190 of about 3,716,507 (339)

Spatial distribution and geospatial modeling of potential spread of secondary malaria vectors species in Nigeria using recently collected empirical data. [PDF]

PLoS One
Adeogun AO, Babalola AS, Oyale OO, Oyeniyi T, Omotayo A, Izekor RT, Adetunji O, Olakiigbe A, Olagundoye O, Adeleke MA, Ojianwuna CC, Dagona A, Muhammad DA, Mabu JM, Sambo EO, Oduola A, Inyama PU, Samdi L, Obembe A, Dogara MM, Yoriyo KP, Mohammed S, Samuel RN, Amajoh C, Musa A, Zabiri MJ, Sani N, Zakariya S, Samaila A, Abba E, Shuaibu AB, Enwemiwe V, Esiwo E, Danjuma A, Shuaibu T, Istifanus PA, Kabiru S, Ukubuiwe AC, Salihu IM, Bamidele JA, Fawole JK, Liatu GC, Wahedi AJ, Idris SF, Ado A, Pukuma MS, Fasasi KA, Rufai AM, Fagbohun IK, Bala M, Esema M, Omo-Eboh M, Idowu OA, Ande A, Olayemi IK, Yayo AM, Ademu C, Okoronko C, Ozor L, Ssekitooleko J, Mokuolu O, Kawu I, Ntadom G, Salako B, Awolola S.   +64 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

CRISPR/dCas9-targeted H3K27me3 demethylation at the CUC3 boundary gene triggers ectopic transcription and impacts plant development

iScience
Summary: Chromatin modifications are deemed to correlate with gene expression patterns, yet their direct causal effect on transcription and cell fate remains unestablished. The H3K27me3 modification, highly conserved in eukaryotes, is strongly associated
Kateryna Fal, Salim El Khoury, Marie Le Masson, Alexandre Berr, Cristel C. Carles   +4 more
doaj  

Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study. [PDF]

Brain Behav Immun Health
Biaggi A, Zonca V, Anacker C, Begni V, Benedetti F, Bramante A, Braniecka A, Brenna V, Bulgheroni M, Buss C, Cavaliere L, Cecil CAM, Couch AC, de Barra D, El Marroun H, Entringer S, Grassi-Oliveira R, Jackowska M, Korosi A, Kwant PJC, Lahti J, Lekadir K, Mansuy I, Manuella F, Marizzoni M, Meyer U, Monk C, Radoš SN, Pariante CM, Pollux BJA, Priestley K, Räikkönen K, Richetto J, Riva MA, Rothmann LM, Simonetti V, Vai B, Vernon AC, Žutić M, Cattaneo A, HappyMums Consortium.   +40 more
europepmc   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Identification of deferasirox as a human xanthine oxidase inhibitor. [PDF]

Life Med
Qi Y, He X, Wu X, Zhou T, Liang N, Jiao J, Chen Y, Yuan Y, Zhang Y, Wang Y, Liu Y, Ding Q.   +11 more
europepmc   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Development of a Methodology for Assessing Mechanical Damage in Biological Objects: Impact Parameters and Micro-Damage Analysis. [PDF]

Materials (Basel)
Kharchenko S, Samborski S, Al Afif R, Kharchenko F, Kłonica M, Piven M.   +5 more
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source