Results 201 to 210 of about 568,188 (255)

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Intelligent therapeutic robotic-assisted surgery as the next frontier of precision oncology. [PDF]

Front Oncol
Satyam SM, Wali AF, El-Tanani M, Sarfraz A, Khalil I, Alghoul WI, Bhat AA, Mansor I, Alhammadi MA, Al-Shammari WBJ, Nasser RAS, Menon A, Alahmad OM.   +12 more
europepmc   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Protocol for developing digital 3D zoological collections for research and academic training in a biodiversity global crisis scenario. [PDF]

STAR Protoc
Delgado C, Lillo A, Cuevas C, Tavera L, Vega E, Gamonal F, Norambuena J, Hernández CE.   +7 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Templateless crystallization of holococcolith crystals visualized by intracellular site-specific three-dimensional microscopy. [PDF]

PNAS Nexus
Ben-Joseph O, Meng YF, Aram L, Abu Freha I, Lansky Z, Safadi R, de Haan D, Rechav K, Kaplan-Ashiri I, Varsano N, Gal A.   +10 more
europepmc   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Introducing azobenzenes as solid phase peptide synthesis linkers. [PDF]

RSC Chem Biol
Śmieja CB, Xin L, Tang T, Tan R, Lee M, Hulme AN.   +5 more
europepmc   +1 more source

Dopamine and its receptor <i>DcDop2</i> are involved in the coevolution between '<i>Candidatus</i> Liberibacter asiaticus' and <i>Diaphorina citri</i>. [PDF]

Elife
Nian X, Li J, Huang J, Yuan W, Holford P, Beattie GAC, He J, Cen Y, He Y, Zhang S.   +9 more
europepmc   +1 more source

Antiviral Mechanisms of Justicidin B and Tuberculatin from <i>Phyllanthus brasiliensis</i> against Oropouche Virus Infection. [PDF]

ACS Omega
Bueno da Silva Menegatto M, Coelho Ferraz A, Lima RLS, René Ruiz Hernández A, Henrique Guimarães P, Alves Machado-Junior P, Gomes PWP, Pamplona SDGSR, Meneses Silva ER, Gonçalves de Oliveira E, Reis ACC, de Magalhães JC, Brandão GC, Coelho-Dos-Reis JGA, Kroon EG, E Silva CYY, da Silva MN, Magalhães CLB.   +17 more
europepmc   +1 more source