Results 191 to 200 of about 3,716,507 (339)

Activation of ductal progenitor-like cells from adult human pancreas requires extracellular matrix protein signaling

iScience
Summary: Ductal progenitor-like cells are a sub-population of ductal cells in the adult human pancreas that have the potential to contribute to regenerative medicine.
Heather N. Zook, Janine C. Quijano, Jose A. Ortiz, Cecile Donohue, Kassandra Lopez, Wendong Li, Neslihan Erdem, Kevin Jou, Christiana J. Crook, Isaac Garcia, Jr., Fouad Kandeel, Enrique Montero, Hsun Teresa Ku   +12 more
doaj  

MetAssimulo 2.0: a web app for simulating realistic 1D and 2D metabolomic 1H NMR spectra. [PDF]

Bioinformatics
Yan Y, Jiménez B, Judge MT, Athersuch T, De Iorio M, Ebbels TMD.   +5 more
europepmc   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, Volume 19, Issue 5, Page 1493-1507, May 2025.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

AgrC biotinylation inhibits Staphylococcus aureus infection. [PDF]

PLoS One
Qian L, He Y, Lian W, Ji Z, Tian Z, Wang C, Cao C, Shern T, Stedman T, Sun Y.   +9 more
europepmc   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Moving toward precision and personalized treatment strategies in psychiatry. [PDF]

Int J Neuropsychopharmacol
Comai S, Manchia M, Bosia M, Miola A, Poletti S, Benedetti F, Nasini S, Ferri R, Rujescu D, Leboyer M, Licinio J, Baune BT, Serretti A.   +12 more
europepmc   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

KLF12 as a potential biomarker for lateral pelvic lymph node metastases in advanced rectal cancer. [PDF]

Cancer Immunol Immunother
Xiao T, Wei F, Zhou S, Zhao F, Huang F, Qian L.   +5 more
europepmc   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Correction: Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3α and/or 3β-HSD neurosteroidogenic enzymes? [PDF]

Neuropsychopharmacology
Osborne LM, Etyemez S, Pinna G, Alemani R, Standeven LR, Wang XQ, Payne JL.   +6 more
europepmc   +1 more source