Results 221 to 230 of about 3,716,507 (339)

Divergent <i>Plasmodium</i> kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis. [PDF]

Life Sci Alliance
Yanase R, Zeeshan M, Ferguson DJ, Markus R, Brady D, Bottrill AR, Holder AA, Guttery DS, Tewari R.   +8 more
europepmc   +1 more source

Revealing protein structures: crystallization of protein‐ligand complexes – co‐crystallization and crystal soaking

FEBS Open Bio, Volume 15, Issue 4, Page 542-550, April 2025.
Co‐crystallization crystallizes a protein with its ligand, resulting in protein–ligand complex crystals. In contrast, soaking introduces a ligand into preformed protein crystals, allowing it to bind. Both methods produce crystals for X‐ray diffraction, which generates diffraction patterns that are analyzed to determine the three‐dimensional structure ...
Barbora Kaščáková, Anna Koutská, Michaela Burdová, Petra Havlíčková, Ivana Kutá Smatanová   +4 more
wiley   +1 more source

The effect of time of day on visual reaction time performance in boxers: evaluation in terms of chronotype. [PDF]

Front Physiol
Kurak K, İlbak İ, Stojanović S, Bayer R, İlbak YE, Kasicki K, Ambroży T, Rydzik Ł, Czarny W.   +8 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

A four eigen-phase model of multi-omics unveils new insights into yeast metabolic cycle. [PDF]

NAR Genom Bioinform
Wang L, Li X, Shi J, Li LM.
europepmc   +1 more source

Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus

FEBS Open Bio, Volume 15, Issue 4, Page 608-621, April 2025.
The bacterial cell membrane and cell wall are the primary targets of baicalin. Baicalin increases the permeability of bacterial membranes, allowing oxacillin sodium to easily penetrate the cells and effectively exert its antimicrobial activity. Methicillin‐resistant Staphylococcus aureus (MRSA) poses a challenge for clinical treatment and combining ...
Xin Meng, Mengna Kang, Zhiyun Yu, Changyou Li, Yang Chen, Taicheng Jin, Kai Wang, Haiyong Guo   +7 more
wiley   +1 more source

Extract optimization and biological activities of Otidea onotica using Artificial Neural Network-Genetic Algorithm and response surface methodology techniques. [PDF]

BMC Biotechnol
Sevindik M, Bal C, Krupodorova T, Gürgen A, Eraslan EC.   +4 more
europepmc   +1 more source

Evaluating frailty scores across experimental groups in rodent models: bridging physical and cognitive domains

FEBS Open Bio, Volume 15, Issue 4, Page 599-607, April 2025.
Method for Frailty Score (FS) calculation: (1) Combine all animals that will be compared in one group; (2) Calculate 20% cutoff; (3) Determine the number of animals that ‘failed’ or ‘passed’; (4) Calculate ‘percentage of success’ for graphical representation of parameters; (5) Repeat for all parameters; (6) Calculate FS and use percentages for ...
Aleksandra Mladenovic, Smilja Pracer
wiley   +1 more source

Multivariate analysis of immunosenescence data in healthy humans and diverse diseases. [PDF]

Front Aging
Añé-Kourí AL, Palomino JL, Lorenzo-Luaces P, Sanchez L, Ledon N, Pereira K, Hernandez JC, Suárez GM, García B, González A, Saavedra D, Lage A.   +11 more
europepmc   +1 more source

Real‐world genomic landscape of colon and rectal cancer

FEBS Open Bio, Volume 15, Issue 4, Page 674-685, April 2025.
We confirmed enrichment of RTK alterations in patients with RAS/BRAF‐wt tumors and of PI3K pathway alterations in RAS/BRAF‐altered tumors with 51 982 real‐world tissue comprehensive genomic profiling (CGP) samples in CRC. In a subset of 140 patients with both tissue and liquid results, the sensitivity of liquid for results found by tissue was 100% when
Markus Schulze, XiaoZhe Wang, Jawad Hamad, Julia C. F. Quintanilha, Lincoln W. Pasquina, Julia F. Hopkins, Juergen Scheuenpflug, Zheng Feng   +7 more
wiley   +1 more source