Results 121 to 130 of about 1,319,865 (263)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Association of bidi smoking and tobacco-use patterns with cancer risk in India: a multicentre unmatched case-control study (2024-2025). [PDF]

Lancet Reg Health Southeast Asia
Venkatesh U, Bera OP, Santhosh VN, Aggarwal P, Chandra Baishya A, Mundra A, Ahamed F, Singh C, Joshi K, Naik BN, Bhattacharyya H, Shekhar S, Maliye C, Joshi M, Bhandarkar B, Gupta K, Joshi HS, Dutta V.   +17 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Gallstone Ileus Secondary to Cholecysto-Duodenal Fistula in a Middle-Aged Female: A Rare Surgical Emergency and Review of the Literature. [PDF]

Clin Case Rep
Mbuyamba HT, Ruboha CO, Chol TR, Ali BM, Balole CK, Shemweta M, Igoti MJ, Machage M, Musa B, Kitua DW, Mchele GM, Mwanga AH, Uwonda SA.   +12 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Longitudinal changes in body composition and water turnover in a world-class male judo athlete: A case report. [PDF]

Physiol Rep
Takubo N, Kondo E, Uchizawa A, Hiraoka H, Masuchi K, Okada H, Sagayama H.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Developing internationally agreed core indicators for surveillance of preconception health: protocol for a consensus study. [PDF]

PLoS One
Schoenaker D, Hall J, Al-Jayyousi GF, Borges ALV, Boua PR, Chan JKY, Chitashvili T, Delbaere I, Demidova A, Fikadu K, Fisher S, Hazra A, James S, Ku CW, Maeda E, Memon Z, Munblit D, Mulders A, Murira Z, Norman WV, Ogle A, Sethi V, Shahbic HI, Kakoly NS, Verbiest S, Stephenson J, International Core Indicators for Preconception Health and Equity (iCIPHE) Alliance.   +26 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

ECHO-T2D - economic, clinical epidemiologic, and humanistic profiling of diabetic retinopathy, diabetic kidney disease, and painful diabetic peripheral neuropathy in India: A systematic review protocol. [PDF]

MethodsX
Shamim MA, Tiwari K, Shukla R, Swami MK, Srivastav S, Meena S, Chaturvedy M, Panda S, John D, Shamim MA, Varthya SB, Singh S, Dwivedi P.   +12 more
europepmc   +1 more source