Results 131 to 140 of about 1,465,762 (307)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
BMC Public HealthBackground Given the rapid proliferation and use of online health resources, many of which may be of dubious quality, there is an increasing need to develop electronic health literacy (e-health literacy) skills among the population of internet users.
Gregor Petrič, Sara Atanasova
doaj +1 more source
New methodology in biomedical science: methodological errors in classical science.
Medicina (Kaunas, Lithuania), 2006 The following methodological errors are observed in biomedical sciences: paradigmatic ones; those of exaggerated search for certainty; science dehumanisation; deterministic and linearity; those of making conclusions; errors of reductionism or quality decomposition as well as exaggerated enlargement; errors connected with discarding odd; unexpected or ...
openaire +1 more source
, 1982 Logic, Methodology and Philosophy of Science VI.Includes bibliographical references and index.Electronic reproduction.Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version
Cohen, L. Jonathan(Laurence Jonathan) +1 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
MACHLUP, Fritz. Methodology of Economics and Other Social Sciences
Estudios Económicos, 1983 MACHLUP, Fritz.
Uros Bacic
doaj +2 more sources
Training needs of the health sciences librarians in Greece
, 2010 The aim of this study is to determine the training needs of the Greek health sciences librarians. Quantitative and qualitative data were collected from 48 questionnaires and individual semi-structured interviews with three librarians.
Kalogeraki, Eleni, Tsalapatani, Eirini
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source