Results 141 to 150 of about 1,465,762 (307)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Health Sciences Cost Construction Study
, 1983 This is a report to communicate further details of the Health Sciences cost construction. While the report includes a discussion of cost construction methodology in general, the main purpose of this transmittal is to set forth the completed Cost ...
University of Minnesota. Health Sciences Center
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Teaching Methodology (Economic Management Sciences)
, 2016 Exam paper for first semester: Teaching Methodology (Economic Management ...
University of Johannesburg
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"Loneliness is killing me" : life stories and resilience of Canadian immigrant women [PDF]
, 2011 xiii, 262 leaves ; 29 cmThe purpose of this study was to explore the experiences and life-stories of recent Canadian immigrant women and their resilience in every day life.
University of Lethbridge. Faculty of Health Sciences +1 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Subject Methodology Physical Sciences(Supplementary)
, 2015 Exam paper for second semester:Subject Methodology Physical Sciences(BEd./PGCE Science and Technology Education ...
University of Johannesburg
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
REFLECTIONS ABOUT THE SCIENCES
, 2010 It is reflected about the Sciences. First of all, it is examined what would be constitution of a theory, getting together theory and practice in a way to reflect about the process of scientific production.
Rodolfo Coutinho Moreira Xavier
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