Results 81 to 90 of about 3,630,829 (295)
The determinants of footballers' effectiveness in a German club
Quality in Sport, 2019 The assessment of footballers effectiveness is the key element of control at every step of their training, regardless of on what level they are. What seems essential is the prediction of footballers' actions, the height of which is achieved in the time ...
Paweł Kalinowski +5 more
doaj +1 more source
Methodology of civil law science
The Journal of V. N. Karazin Kharkiv National University, Series "Law", 2019 The article deals with the methods of scientific researches in civil law such as dialectic, method of formal logic and method of structural system. The characteristics of these methods are also studied. The article supports thesis on dialectic being the most common method in legal researches, while other methods of scientific knowledge complete ...
openaire +3 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Royal Society Open ScienceWe present a scoping review of methodological papers in the social science literature covered in Scopus from 2017 to 2022. In this review, we document the shared norms, ideals and practices regarding the quality of qualitative research methodology.
Xavier Salet +3 more
doaj +1 more source
Trials, 2018 Background Core outcome set (COS) developers increasingly employ Delphi surveys to elicit stakeholders’ opinions of which outcomes to measure and report in trials of a particular condition or intervention.
Sara T. Brookes +5 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Abstract Over our species’ history, we evolved methodological abilities of the mind (observation, problem solving and experimentation) that we use together with increasingly complex methods developed using these abilities (controlled experimentation, statistics and X-ray methods).
openaire +1 more source
Newton's "Experimental Philosophy" [PDF]
, 2002 My talk today will be about Newton’s avowed methodology, and specifically the place of experiment in his conception of science, and how his ideas changed significantly over the course of his career.
Shapiro, Alan E.
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source