Results 61 to 70 of about 844,099 (264)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Numerical analysis of structure preserving Nyström methods for Hamiltonian systems

open access: yes, 2005
Energy conservation is an essential property of conservative mechanical systems that should be carried over to the numerical solution. Betsch and Steinmann proposed recently perturbed potentials to achieve energy conservation in the time integration of N-
Pfeiffer, Andreas, Arnold, Martin
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Survey on the Numerical Methods for ODE's Using the Sequence of Successive Approximations

open access: yes, 2005
Here we present the error estimations in the numerical methods for Cauchy problems corresponding to ODE’s, which use the sequence of successive approximations and quadrature rules such as trapezoidal rule and perturbed trapezoidal ...
Bica, Alexandru Mihai
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Efficient numerical methods for Volterra integral equations of Hammerstein type

open access: yes, 2006
Volterra integral equations (VIEs) are the mathematical model of many evolutionary problems with memory arising from biology, chemistry, physics, engineering.
Del Prete, Ida
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Numerical methods for ordinary differential equations with applications to partial differential equations

open access: yes, 1983
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The thesis develops a number of algorithms for the numerical solution of ordinary differential equations with applications to partial differential equations.
Khaliq, Abdul Qayyum Masud
core  

MultiFEBE: An open-source multi-domain integrated finite element and boundary element software

open access: yes, 2022
This paper presents MultiFEBE: an open-source solver for multi-domain integrated Finite Element and Boundary Element models for linear static and time harmonic analysis based on an integration of several BEM-FEM models for soil-shell and soil-beam ...
Álamo Meneses, Guillermo Manuel   +5 more
core  

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