Results 31 to 40 of about 83,883,403 (289)
Langrangian finite element and finite difference methods for poisson problems [PDF]
, 1974 The use of Lagrangian finite element methods for solving a Poisson problem produces systems of linear equations, the global stiffness equations. The components of the vectors which are the solutions of these systems are approximations to the exact ...
Whiteman, J R
core +6 more sources
A method for solving synchronization problems
Science of Computer Programming, 1989 AbstractThis paper presents a systematic method for solving synchronization problems. The method is based on viewing processes as invariant maintainers. First, a problem is defined and the desired synchronization property is specified by an invariant predicate over program variables.
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Simple methods of engineering calculation for solving heat transfer problems
Mathematical Modelling and Analysis, 2003 There are well‐known numerical methods for solving the initial‐boundary value problems for partial differential equations. We mention only some of them: finite difference method (FDM), finite element method (FEM), boundary element method (BEM), Galerkin ...
H. Kalis, I. Kangro
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Applications of Ontologies and Problem Solving Methods
AI Mag., 1999 The Workshop on Applications of Ontologies and Problem-Solving Methods (PSMs), held in conjunction with the Thirteenth Biennial European Conference on Artificial Intelligence (ECAI ’98), was held on 24 to 25 August 1998. Twenty-six people participated, and 16 papers were presented.
Gómez-Pérez, A., Benjamins, Richard
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Using Local Search Methods for Solving Two Multi-Criteria Machine Scheduling Problems
Al-Mustansiriyah Journal of Science, 2023 In this paper, we have improved solutions for two of the Multi-Criteria Machine Scheduling Problems (MCMSP). These problems are to maximize early jobs time and range of lateness jobs times (1//(E_max,R_L ), and the second problem is maximum tardy jobs ...
Safanah Faisal Yousif +2 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Methods for Solving Linear Programming Problems Using Modern Computer Technologies
Цифрова платформа: інформаційні технології в соціокультурній сфері, 2018 The purpose of the article is to improve the study of such software products, as systems of the automated engineering’s and economic calculations of Excel and MathCAD which are resulted the detailed decision of optimization task, as to one of major and ...
Iryna Ovcharuk, Volodymyr Ovcharuk
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