Results 51 to 60 of about 87,565,261 (298)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Orthogonal methods based ant colony search for solving continuous optimization problems [PDF]

, 2008
Research into ant colony algorithms for solving continuous optimization problems forms one of the most significant and promising areas in swarm computation.
Jun Zhang, Yun Li 李 耘, Hu, X., Xiao-min Hu, Li, Y., Zhang, J.   +5 more
core   +1 more source

Marketing methods for solving management problems of higher educational institutions

Наукові Записки Наукма: Соціологія, 2018
Educational management is a complex, hierarchically organized structured subsystem of the general education system, able to provide its performance and development while maintaining the basic quality parameters using social technologies of developmental ...
Yana Dubinina
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Application of statistical methods for solving problems of construction materials science

Нанотехнологии в строительстве, 2020
In the areas of construction materials science, the most promising solution is a set of issues related to the study of the influence of conditions for the formation of the material structure, including the possibilities of its self-organization, on its ...
Aleksey D. Zhukov
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Some methods for solving boundary value problems for polyharmonic equations

Қарағанды университетінің хабаршысы. Математика сериясы
This article consists of three sections. In the first section the concept of Vekua space is introduced, where for elliptic systems of the first order, the theorem on the representation of the solution of a homogeneous equation and the theorem on the ...
M.T. Sabirzhanov, B.D. Koshanov, N.M. Shynybayeva, P.Zh. Kozhobekova   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spreadsheet Implementations for Solving Boundary-Value Problems in Electromagnetics [PDF]

, 2010
Electromagnetics is arguably one of the most challenging courses in any electrical engineering curriculum. A solid foundation in vector calculus and a good intuition based on physical grounds are the normal requirements for a student to successfully ...
Sastry P Kuruganty, Mark A Lau
core